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West Nile Virus (WNV) Infection

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West Nile Virus (WNV) Infection

At our company, we are committed to advancing the diagnosis of West Nile virus infection by developing customized IVD solutions. By leveraging cutting-edge technology and expertise, we strive to improve the accuracy and efficiency of West Nile virus diagnostics, ultimately contributing to better treatment and intervention.

Introduction to West Nile Virus Infection

West Nile virus (WNV) is a flavivirus that primarily spreads through mosquito bites. The virus was first identified in the West Nile district of Uganda, hence its name. Most individuals infected with WNV remain asymptomatic, while about 20% may develop symptoms such as fever, headache, muscle aches, and rash. In severe cases, WNV can lead to encephalitis or meningitis, causing serious brain and spinal cord inflammation.

Mechanisms of West Nile virus (WNV) infection of the nervous system.Fig. 1 Mechanism of neuroinvasion of West Nile virus (WNV). (Cho, Hyelim, and Michael S. Diamond., 2012)

Diagnostic Biomarkers for West Nile Virus Infection

Diagnostic biomarkers play a vital role in the accurate and timely detection of infectious diseases such as West Nile virus (WNV) infection. These biomarkers are measurable indicators that indicate the presence of a disease or infection in the body. Identifying specific biomarkers can help with early diagnosis, monitoring disease progression, and evaluating therapeutic response.

Genetic Testing

Viral antigens are proteins derived from West Nile virus, such as E protein and NS1 protein, that trigger the host's immune response. Antigen detection tests directly identify viral proteins present in a sample, indicating the presence of active West Nile virus infection.

Antigens

Biochemical Assays

Antibodies, particularly IgM and IgG, are produced by the host's immune system in response to WNV infection. ELISA or immunofluorescence assays are used to detect WNV specific antibodies, which can indicate previous exposure to the virus or an ongoing immune response.

Antibodies

Point-of-Care Testing

Viral RNA refers to the genetic material of West Nile virus (WNV) and can be detected in samples during active infection. Real-time PCR is often used to quantify viral RNA levels and confirm WNV infection in blood, cerebrospinal fluid, or tissue samples.

Viral RNA

IVD Development for West Nile Virus Infection

In vitro diagnostic (IVD) tests are pivotal in identifying and controlling infectious diseases like West Nile virus (WNV). The development of accurate and reliable WNV IVD kits is essential for prompt diagnosis, disease control, and public health monitoring. Shown below are some of the types of kits that can be developed.

Kits Applications Detection Methods
West Nile Virus PCR Detection Kit Quantification of viral RNA levels and determination of viral load. PCR
West Nile Virus Rapid Antigen Test Kit Qualitative detection of West Nile virus antigen in samples. Immunochromatographic Assay
West Nile Virus Antibody Test Kit Quantitative and qualitative immunoassays for West Nile virus IgG and IgM antibodies in serum. ELISA

Our Services

Through in-depth exploration of the pathogenesis associated with West Nile virus (WNV) infection, we are dedicated to crafting pioneering IVD solutions for the accurate detection and efficient control of this infectious disease. Our offerings encompass the design of IVD kits for detecting antigens, antibodies, and RNA, alongside user-friendly diagnostic devices. Our aim is to transform WNV diagnostics by creating cutting-edge IVD products.

Recognizing the significance of point-of-care testing (POCT) in areas with limited resources, our experts specialize in creating swift diagnostic assays for immediate on-site detection of West Nile virus (WNV) infection. Our companion diagnostic development services concentrate on integrating diagnostic assays with tailored therapeutics to facilitate individualized care for WNV.

If you are interested in our services, please feel free to contact us for more details and quotation information of related services.

Reference

  1. Cho, Hyelim, and Michael S. Diamond. "Immune responses to West Nile virus infection in the central nervous system." Viruses 4.12 (2012): 3812-3830.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.