Marburg virus disease is classified as a viral hemorrhagic fever. Dedicated to pushing the diagnostic boundaries of Marburg virus disease, our company leads the way in crafting tailored IVD solutions. By innovating groundbreaking IVD kits and automated diagnostic devices, our mission is to revolutionize the detection and management of this disease.
Overview of Marburg Virus Disease
Marburg virus disease (MVD) is a severe illness caused by the Marburg virus of the Filoviridae family. This rare yet deadly disease is marked by flu-like symptoms that can swiftly advance to severe complications such as bleeding, organ failure, and shock. The virus is mainly spread to humans through contact with infected bats or primates, with human-to-human transmission possible via exposure to bodily fluids. MVD is categorized as a viral hemorrhagic fever, and early detection improvements are crucial in the fight against this lethal infectious disease.
Fig. 1 Pathogenesis of severe viral hemorrhagic fever. (Flórez-Álvarez, et al., 2022)
Diagnostic Biomarkers for Marburg Virus Disease
The identification and validation of diagnostic biomarkers such as viral antigens, viral RNA, and antibodies are crucial for the development of sensitive, specific, and reliable diagnostic assays for Marburg virus disease (MVD). These biomarkers play a pivotal role in early detection, monitoring of disease progression, and implementation of effective control measures to combat this severe viral illness.
Viral Antigens
Viral antigens are proteins expressed by the Marburg virus that serve as direct indicators of active infection. In MVD diagnostic testing, detection of viral antigens such as nucleoprotein (NP) or glycoprotein (GP) of the Marburg virus in blood, serum or tissue samples serves as direct evidence of the presence of the virus.
Viral RNA
Detection of viral RNA by molecular techniques such as reverse transcription polymerase chain reaction (RT-PCR) is a sensitive and specific method for diagnosing MVD. Viral RNA is a critical biomarker because it directly indicates the presence of viral genetic material in a sample, even at low concentrations.
Antibodies
Antibodies produced by the host immune system in response to Marburg virus infection are important diagnostic biomarkers. IgM antibodies are usually detectable during the acute phase of infection, indicating recent exposure to the virus. In contrast, IgG antibodies are produced later and provide long-term immunity.
IVD Development for Marburg Virus Disease
The development of in vitro diagnostic (IVD) solutions for Marburg virus disease entails the design and manufacture of specialized tools for detecting the presence of the Marburg virus in samples. IVD kits are essential for ensuring the precise and prompt identification of this severe and potentially deadly illness. The development of tailored diagnostic kits may concentrate on the following aspects:
Antigen Detection Kit Development
Antigen detection kits are designed to identify specific viral antigens in samples. These kits utilize techniques like ELISA or lateral flow assays for rapid and specific detection of viral antigens, providing evidence of active infection.
Marburg Virus RNA Detection Kit Development
RT-PCR test targets and amplifies viral RNA in a sample to detect genetic material of the Marburg virus. The RT-PCR test kit is highly sensitive and specific, allowing for early and accurate diagnosis of Marburg virus disease.
IgM/IgG Antibody Detection Kit Development
Serological assays detect antibodies produced by the host immune system in response to Marburg virus infection. ELISA or indirect fluorescent antibody tests (IFAT) can be employed to detect Marburg virus-specific IgM and IgG antibodies in sera, aiding in the diagnosis and monitoring of immune response.
Point-of-care Test (POCT) Kit Development
Point-of-care tests (POCT) are rapid diagnostic tools that can be used at the bedside or in remote settings to provide immediate results. Developing rapid lateral flow assays or similar tests for the detection of Marburg virus antigens or antibodies can enable quick diagnosis and decision-making in resource-limited environments.
Our Services
As a frontrunner in the field of infectious disease diagnostic development services, we specialize in delivering cutting-edge IVD solutions for Marburg virus disease (MVD) to address intricate diagnostic requirements. Our proficiency centers around crafting IVD reagents/kits and state-of-the-art diagnostic devices tailored exclusively for MVD, elevating diagnostic automation standards and facilitating the effective management of MVD.
IVD Product Development Services
Optional IVD Products
- Nucleoprotein (NP) Detection Kit
- Glycoprotein (GP) Detection Kit
- RNA Detection Kit
- IgM/IgG Detection Kit
- Primers and Probes
- RNA Extraction Reagents
- PCR Reagents
- And More
Our point-of-care testing (POCT) development services are tailored to create portable and user-friendly diagnostic tools for prompt on-site detection of Marburg virus infection. Furthermore, we offer companion diagnostic development services to pinpoint biomarkers linked to disease progression and therapeutic response, guiding the formulation of personalized care strategies.
If you are interested in our services, please feel free to contact us for more details and quotation information of related services.
Reference
- Flórez-Álvarez, Lizdany, et al. "Hemorrhagic fever viruses: Pathogenesis, therapeutics, and emerging and re-emerging potential." Frontiers in Microbiology 13 (2022): 1040093.
All of our services and products are intended for preclinical research use
only and cannot be used to diagnose, treat or manage patients.
