Rapid and efficient diagnosis is crucial for Chikungunya prevention and intervention. With a team of researchers and scientists well versed in Chikungunya, our company is dedicated to developing advanced IVD products for Chikungunya. We also provide point-of-care testing and companion diagnostic development services to facilitate rapid diagnosis and personalized therapeutics of Chikungunya.
Introduction to Chikungunya
Chikungunya, caused by the Chikungunya virus, has emerged as a significant global health concern. This virus is primarily transmitted through mosquito bites, attacking human immune cells and fibroblast cells, leading to virus replication and triggering host immune responses. The hallmark symptoms of chikungunya, including fever and joint pain, are attributed to the inflammatory responses elicited by the virus.
Fig. 1 Schematic diagram of the spread of Chikungunya virus. (Silva Jr J V J, et al., 2018)
Diagnostic Biomarkers for Chikungunya
Due to the overlap of symptoms between Chikungunya and other viral illnesses, diagnosis may be extremely challenging. Diagnostic biomarkers provide specific and sensitive indicators of the presence, progression, or therapeutic response of the disease.
Viral RNA
Detection of chikungunya viral RNA through molecular techniques like PCR and microarray analysis serves as a direct indicator of active infection. Quantifying viral load aids in tracking disease progression and therapeutic response.
Specific Antibodies
Immunoglobulin M (IgM) antibodies against chikungunya virus are typically detectable during the acute phase of infection, indicating recent exposure. IgG antibodies, persisting for a longer duration, suggest past infection or immunity.
Cytokines and Chemokines
Elevated levels of pro-inflammatory cytokines (e.g., IL-6, TNF-α) and chemokines in serum have been associated with the inflammatory response in chikungunya infection. Monitoring these markers provide insights into disease severity.
IVD Kits for Chikungunya
In vitro diagnostic (IVD) kits for Chikungunya are essential tools for the accurate detection and diagnosis of Chikungunya virus infection. These kits are designed to detect specific biomarkers of the virus, such as viral RNA or antibodies. Here are some common types of IVD kits used for Chikungunya diagnosis.
| Kits |
Applications |
Detection Methods |
| Chikungunya Virus RNA Detection Kits |
Qualitative detection of Chikungunya virus RNA in samples. |
Reverse transcription polymerase chain reaction (RT-PCR) |
| Chikungunya Serology Kits |
Used to differentiate between IgM (indicating recent infection) and IgG (indicating past infection or immunity) antibodies. |
Immunofluorescence assay |
| Rapid Immunochromatographic Test Kits |
These kits are convenient point-of-care tests that detect Chikungunya virus-specific antibodies in blood samples. |
Immunochromatographic assay |
| Chikungunya IgM Rapid Test Kits |
Qualitative detection of IgM anti-chikungunya virus in serum, plasma or whole blood. |
Lateral flow chromatographic immunoassay |
Our Services
At our company, we are dedicated to advancing
IVD solutions for Chikungunya. Our primary focus lies in creating Chikungunya virus
RNA and
antigen detection kits to precisely distinguish Chikungunya from other
infectious diseases that present similar symptoms. Through the development of
antibody
point-of-care test kits, our goal is to streamline the swift screening of pathogens in settings where resources are limited.
Workflow of IVD Reagent/Kit Development
By developing cutting-edge
diagnostic equipment, we have markedly improved the automation and efficiency of Chikungunya diagnosis. Our
companion diagnostic development services underscore the integration of diagnostic testing with therapeutic interventions to tailor personalized therapeutic strategies.
IVD Device Development Services
If you are interested in our services, please don't hesitate to
reach out to us for further information and pricing details on the services we offer.
Reference
- Silva Jr J V J, Ludwig-Begall L F, de Oliveira-Filho E F, et al. A scoping review of Chikungunya virus infection: epidemiology, clinical characteristics, viral co-circulation complications, and control[J]. Acta tropica, 2018, 188: 213-224.
All of our services and products are intended for preclinical research use
only and cannot be used to diagnose, treat or manage patients.
