Typhoid fever continues to pose a global health challenge. Our company boasts a skilled team of researchers and scientists specializing in typhoid fever, dedicated to pioneering cutting-edge IVD solutions. Furthermore, we offer point-of-care testing (POCT) and companion diagnostic development services to enhance prompt diagnostics and individualized therapeutic options for typhoid fever.
Introduction to Typhoid Fever
Typhoid fever, caused by the bacterium Salmonella typhi (S. typhi), is a major health problem worldwide, especially common in areas with poor sanitation and lack of clean water. This infectious disease primarily affects the gastrointestinal system, causing symptoms such as high fever, abdominal pain, rash, and gastrointestinal disturbances. The ability of individuals to remain asymptomatic carriers of the disease poses challenges for effective prevention and control strategies. According to estimates, 11 million to 21 million cases occur annually worldwide, underscoring the urgent need for improved diagnostic tools.
Fig. 1 Dissemination of S. typhi during systemic infection. (De Jong, Hanna K., et al., 2012)
Diagnostic Biomarkers for Typhoid Fever
Diagnostic biomarkers for typhoid fever serve as measurable indicators of the presence of the disease, providing valuable information about the host-pathogen interaction, disease severity, and therapeutic response. These biomarkers can be detected in various biological samples, including blood, urine, stool, and saliva, offering diverse avenues for diagnostic testing.
Antigens
The key antigens associated with S. typhi include the O antigen and the Vi capsular antigen. Detection of the O antigen and the Vi capsular antigen in a sample indicates the presence of S. typhi and aids in the diagnosis of typhoid fever. Various serological tests are available to identify the bacteria.
Antibodies
After infection with S. typhi, the immune system produces specific antibodies against the bacteria, including IgM and IgG. Detection of these antibodies in serum samples can provide insight into the stage of infection and help differentiate between recent and past infections.
Bacterial DNA
PCR-based assays target the specific DNA sequences of S. typhi, enabling the direct detection of the pathogen in samples such as blood, stool, or urine. PCR offers rapid and sensitive detection of the bacterium, aiding in early diagnosis and therapeutic initiation for typhoid fever.
IVD Kits for Typhoid Fever
In the diagnosis of typhoid fever, in vitro diagnostic (IVD) kits play a pivotal role by offering rapid, accurate, and convenient testing solutions that aid in the timely detection and management of the disease. These kits enable healthcare providers to efficiently identify specific biomarkers associated with typhoid fever, such as antigens, antibodies, and DNA, facilitating early intervention. The following are some typhoid IVD kits currently available on the market.
| Kits |
Applications |
Detection Methods |
| Typhoid Fever IgG/IgM Rapid Test Kit |
Qualitative detection of S. typhi specific IgG and IgM antibodies in serum, plasma and whole blood samples. |
Immunochromatographic Assay |
| S. typhi Antigen Rapid Test Kit |
Simultaneous detection and differentiation of S. typhi and S. paratyphi antigens in stool and blood culture specimens. |
Lateral Flow Chromatographic Immunoassay |
| S. typhi DNA Detection Kit |
Qualitative detection of S. typhi DNA. |
PCR |
Our Services
At our company, we excel in crafting custom IVD solutions for detecting typhoid fever. Our steadfast dedication lies in developing state-of-the-art antigen, antibody, and DNA testing kits tailored for the detection of Salmonella typhi. By pioneering advancements in supplementary diagnostic devices, our goal is to streamline the process of diagnosing and managing typhoid fever efficiently.
Recognizing the significance of point-of-care testing (POCT) in areas with limited resources, our researchers specialize in creating swift diagnostic assays for immediate typhoid fever identification at the site. Our companion diagnostic development services emphasize the integration of diagnostic tests with tailored therapeutics to facilitate individualized care of typhoid fever.
If you are interested in learning more about our services, please do not hesitate to contact us for additional details and pricing information.
Reference
- De Jong, Hanna K., et al. "Host–pathogen interaction in invasive salmonellosis." (2012): e1002933.
All of our services and products are intended for preclinical research use
only and cannot be used to diagnose, treat or manage patients.
