Rheumatoid arthritis is recognized as a chronic systemic, multifactorial, inflammatory, and progressive autoimmune condition. As a frontrunner in rare disease diagnostic development, our company boasts seasoned experts in rheumatoid arthritis. Driven by a commitment to excellence and innovation, we offer comprehensive diagnostic development solutions, including state-of-the-art IVD products, point-of-care testing, and companion diagnostic development services.

Overview of Rheumatoid Arthritis

Rheumatoid arthritis is a persistent, inflammatory, systemic autoimmune disorder linked to advancing disability, systemic complexities, and premature mortality. Its prevalence falls within the range of 0.5% to 1.0% in the United States.

Rheumatoid arthritis is marked by synovial inflammation and hyperplasia, the generation of autoantibodies such as rheumatoid factor (RF) and anti-citrullinated protein antibody (ACPA), as well as the development of cartilage and bone malformations. Additionally, it presents systemic manifestations including cardiovascular, pulmonary, psychological, dermatological, and musculoskeletal issues.

Fig.1 The contrast between ACPA-positive B cells and RF-positive B cells. (Jang, S., et al., 2022)

Biomarkers Development for Rheumatoid Arthritis

Autoantibodies

Autoantibodies such as rheumatoid factor and anti-citrullinated protein antibody are commonly assessed as serum markers in individuals with rheumatoid arthritis. Additionally, antibodies like anti-CCP and anti-MCV have also been linked to rheumatoid arthritis.

Genetic Markers

Genetic factors like HLA-DRB1 and PTPN22 are believed to play a role in the genetic predisposition to rheumatoid arthritis. Understanding the genetic components involved in rheumatoid arthritis has the potential to lead to improved personalized therapy approaches.

Other Biomarkers

Biomarkers such as IL-6, IL-12, IL-18, 14-3-3η, RANKL, IFN-γ, and TGF-β have been identified as significant biomarkers in rheumatoid arthritis. These biomarkers have the potential to enhance the accuracy and timeliness of diagnosis and aid in predicting disease progression.

IVD Kits for Rheumatoid Arthritis

Our Services

Our diverse team of specialists merges state-of-the-art technologies with a profound comprehension of rare diseases to provide accurate and prompt diagnostic development services. Utilizing cutting-edge tools ranging from advanced genetic testing to pioneering biomarker identification, we harness the most recent innovations to develop IVD products.

Additionally, we provide quick and affordable point-of-care testing and companion diagnostic development services, enabling a comprehensive approach to individual care and therapeutic progress. Through our advocacy for precise diagnostics and individualized therapy pathways, we are committed to creating an enduring influence in rare diseases. If you are interested in our services, don't hesitate to get in touch with us for further details.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.