Hand, foot, and mouth disease (HFMD) is an infectious illness instigated by enterovirus. In response to the diagnostic hurdles associated with HFMD, our company commits resources to cutting-edge technologies and proficient experts focused on crafting IVD solutions. Our groundbreaking diagnostic kits and apparatus aim to notably amplify the sensitivity, specificity, and reliability of testing.
Overview of HFMD
Hand, foot, and mouth disease (HFMD) is a prevalent viral infection that predominantly affects infants and children under the age of five. This contagious infection, characterized by a blister-like rash on the extremities and painful sores in the oral cavity, is typically caused by viruses belonging to the coxsackievirus and enterovirus families. HFMD often spreads swiftly among young children in daycare and school settings, although older children and adults can also be affected.
Fig. 1 The immunopathology of Enterovirus 71 (EV71) and the symptoms it causes. (Cox J A, et al., 2017)
Diagnostic Biomarkers for HFMD
The varied clinical symptoms and viral origin of hand, foot, and mouth disease (HFMD) pose a diagnostic challenge. The identification of specific biomarkers associated with HFMD can significantly enhance early detection, accurate diagnosis, and timely intervention.
Viral RNA
Coxsackievirus and enterovirus RNA in samples such as throat swabs, stool, or blister fluid are key diagnostic biomarkers for HFMD. PCR testing for viral nucleic acids has high sensitivity and specificity in identifying the causative virus, facilitating rapid and accurate diagnosis.
IgM Antibodies
The detection of specific IgM antibodies against HFMD-associated viruses in serum samples can be indicative of recent infection. IgM antibody testing provides insights into the acute phase of the disease, aiding in distinguishing active HFMD cases from past infections.
IVD Kits for HFMD
In the comprehensive management of hand, foot, and mouth disease (HFMD), in vitro diagnostic (IVD) kits play a crucial role by enabling early and accurate diagnosis, supporting disease surveillance efforts, and facilitating personalized therapies. IVD kits for HFMD involve identifying the genetic material of pathogens that cause HFMD, primarily enterovirus A71 (EV71) and coxsackievirus A16 (CoxA16).
CoxA16/EV71/EV-U Real Time PCR Kit
The kit is an IVD reagent based on fluorescent PCR technology, which is used to detect CoxA16, EV71 and universal enterovirus (EV-U) nucleic acids in throat swab samples.
Diagnostic Kit for Coxsackievirus A6 RNA
Coxsackievirus A6 is a positive-strand RNA virus that causes HFMD. This kit is a real-time (rt) reverse transcriptase (RT) polymerase chain reaction (PCR) test intended for the qualitative detection of coxsackievirus A6 nucleic acid from throat swab samples.
Our Services
Our company excels in the provision of diagnostic development services tailored for hand, foot, and mouth disease (HFMD), offering a wide array of IVD solutions to address intricate diagnostic requirements. We specialize in creating nucleic acid, antigen, antibody or microbial detection reagents/kits tailored for HFMD, facilitating early detection and precise diagnosis of this infectious disease.
Workflow of IVD Reagent/Kit Development
Leveraging cutting-edge diagnostic devices, our primary goal is to streamline and automate the diagnostic procedures, ultimately enhancing operational efficiency. Moreover, our services encompass the customization of point-of-care testing (POCT) and companion diagnostics development for uncommon infectious diseases. These services play a crucial role in expediting swift detection and personalized therapies for diseases.
IVD Device Development Services
If you are interested in our services, please feel free to contact us for more details and quotation information of related services.
Reference
- Cox J A, Hiscox J A, Solomon T, et al. Immunopathogenesis and virus–host interactions of enterovirus 71 in patients with hand, foot and mouth disease[J]. Frontiers in microbiology, 2017, 8: 2249.
All of our services and products are intended for preclinical research use
only and cannot be used to diagnose, treat or manage patients.
