The development of IVD tools has significantly improved the diagnosis and management of cryptococcosis. Building upon our innovative work in cryptococcosis research, we lead the way in creating state-of-the-art IVD reagents/kits and devices. Serving as your reliable ally in cryptococcosis diagnostic exploration, we offer unmatched assistance to fulfill your research requirements.
Introduction to Cryptococcosis
Cryptococcosis, a potentially fatal fungal infection caused by Cryptococcus neoformans, poses significant challenges in diagnosis. Cryptococcosis is acquired by inhaling spores of Cryptococcus fungi present in the environment, including soil, decaying wood, and pigeon droppings. The fungi, once inhaled, can colonize the lungs and potentially spread to the brain, leading to severe complications such as meningitis.
Fig. 1 Pathogenesis of cryptococcal meningitis. (Aliyu M, et al., 2022)
IVD Development for Cryptococcosis
Accurate and timely diagnosis of cryptococcosis is essential for initiating appropriate antifungal therapy and improving therapeutic outcomes. IVD development for cryptococcosis focuses on the detection of specific biomarkers associated with the presence of Cryptococcus fungi. Antigen and DNA detection offer distinct advantages in diagnosing and monitoring the progression of cryptococcosis.
Antigen Detection
Antigen detection is crucial in diagnosing cryptococcosis. The primary targets for antigen detection are the capsular polysaccharides of Cryptococcus, particularly glucuronoxylomannan (GXM). Various methods, such as lateral flow assays and ELISA, are employed for antigen detection.
DNA Testing
DNA testing plays a pivotal role in diagnosing cryptococcosis, particularly in cases where antigen detection might yield false negatives. DNA testing enables the direct identification of the fungal pathogen. Common DNA testing techniques include PCR and next-generation sequencing (NGS).
IVD Kits for Cryptococcosis
In vitro diagnostic (IVD) kits are vital for promptly and accurately detecting cryptococcosis, guiding appropriate therapeutic strategies. A variety of IVD kits tailored for cryptococcosis are currently on the market, which contribute to the rapid diagnosis and effective control of this infectious disease.
| Kits |
Applications |
Detection Methods |
| Cryptococcal Antigen Detection Kit |
These rapid tests detect Cryptococcal capsular antigen in samples like cerebrospinal fluid or serum. |
Lateral Flow Assays |
| ELISA Kit for Cryptococcosis Diagnosis |
Identification of cryptococcal antigen. |
ELISA |
| Cryptococcal DNA Detection Kit |
Qualitative detection of cryptococcal DNA. |
PCR |
| Cryptococcal Antigen Latex Agglutination Kit |
Cryptococcal antigen detection. |
Latex Agglutination Tests |
Our Services
Specializing in delivering cutting-edge in vitro diagnostic (IVD) solutions for rare infectious diseases like cryptococcosis, our company is dedicated to developing tailor-made antigen, microbial, and DNA detection kits to enhance early identification and efficient control of cryptococcosis. These kits are used in conjunction with companion diagnostic devices to enhance detection sensitivity and specificity to the fullest extent.
IVD Product Development Services
Furthermore, our services encompass point-of-care testing (POCT) and companion diagnostics development customized for cryptococcosis. These services play a crucial role in enabling rapid disease identification and precise therapeutics of cryptococcosis. If you are interested in our services, please do not hesitate to reach out to us for further information and quotations regarding the related offerings.
Reference
- Aliyu M, Saboor-Yaraghi A A, Khodavaisy S, et al. Glucuronoxylomannan: the salient polysaccharide in cryptococcal immunity[J]. AIMS Allergy and Immunology, 2022, 6(2): 71-89.
All of our services and products are intended for preclinical research use
only and cannot be used to diagnose, treat or manage patients.
