Given the ongoing significance of rabies as a critical public health concern, our company is dedicated to pioneering advanced IVD solutions for the effective management of this lethal infectious disease. Serving as your reliable ally in rabies research, we offer integrated and thorough solutions to address all your research requirements.
Introduction to Rabies
Rabies, a deadly viral disease, poses a significant threat to both human and animal populations worldwide. It is caused by the rabies virus (RABV), primarily transmitted through the saliva of infected animals via bites or scratches. Once symptoms manifest, rabies is almost invariably fatal. The virus targets the central nervous system, leading to severe neurological symptoms and, ultimately, death. Prompt diagnosis and therapeutics are crucial in preventing the progression of the disease.
Fig. 1 Structure of rabies virus. (Fooks, A., et al., 2017)
Diagnostic Biomarkers for Rabies
Due to the lethal nature of rabies, swift and precise diagnostic methods are imperative for efficient disease management and containment. The recognition of dependable biomarkers is crucial for timely detection, prognosis, and monitoring of therapeutics in cases of rabies.
Viral RNA
Viral RNA is a direct indicator of rabies virus replication and transmission within the host. Detection and quantification of viral RNA in biological specimens such as saliva or cerebrospinal fluid can help confirm rabies infection.
Antibodies
Antibodies produced after exposure to the rabies virus are an important component of the immune response. The presence of rabies-specific antibodies in serum or cerebrospinal fluid indicates previous exposure to the virus.
Rabies Virus Antigen
Rabies virus antigen is a key protein component of rabies virus, which plays a vital role in virus invasion and pathogenicity. Rabies virus antigen can be used as a valuable diagnostic biomarker for rabies infection.
IVD Development for Rabies
In vitro diagnostic (IVD) kits play a vital role in the accurate and timely detection of rabies, enabling healthcare providers to confirm infection, monitor disease progression, and guide therapeutic decisions. Development of potential IVD kits for enhanced rabies diagnosis and surveillance could be based on the following strategies.
| Kits |
Description |
| Rabies Virus RNA Detection Kit |
These kits use quantitative PCR testing to accurately quantify viral RNA and determine viral load. |
| Rabies Antibody Detection Kit |
Utilizing serological testing such as ELISA, these kits can be used to detect rabies-specific antibodies in serum or cerebrospinal fluid. |
| Rabies Virus Antigen Test Kit |
These kits commonly employ immunofluorescence assays and ELISA to detect the presence of rabies virus antigens in biological samples. |
| Companion Diagnostic Kits |
These kits are designed to identify biomarkers associated with rabies infection or therapeutic response, such as NSE or GFAP, which can help personalize therapies. |
Our Services
In tackling the intricate landscape of rabies in vitro diagnostics (IVD), our company is dedicated to exploring rabies biomarkers for the creation of RNA, antigen, and antibody test kits. These kits are utilized in combination with our diagnostic devices to ensure optimal performance and accuracy in testing.
Furthermore, we provide point-of-care testing (POCT) and companion diagnostic development services tailored for rabies. These offerings assist in creating portable and intuitive in vitro diagnostic (IVD) tools, enabling swift detection and customized therapeutics of rabies.
If you are interested in our services, please don't hesitate to reach out to us for further information and pricing details on the services we offer.
Reference
- Fooks, A., Cliquet, F., Finke, S. et al. Rabies. Nat Rev Dis Primers 3, 17091 (2017).
All of our services and products are intended for preclinical research use
only and cannot be used to diagnose, treat or manage patients.
