Diphtheria, a bacterial infection with life-threatening potential, is within our realm of deep expertise in diagnostic research. We are adept at providing customized solutions and extensive assistance to guide you seamlessly from diphtheria diagnostic research to the commercialization phase.
Introduction to Diphtheria
Diphtheria, caused by the bacterium Corynebacterium diphtheriae (C. diphtheriae), is a highly contagious infectious disease known for its serious respiratory complications and potential skin manifestations. The bacterium produces a toxin that leads to the formation of grey tissue in the throat, hindering breathing and swallowing. In critical instances, the toxin may infiltrate the bloodstream, leading to systemic complications like nerve impairment, renal dysfunction, and cardiac issues. Timely diagnosis is crucial in halting the advancement of diphtheria to perilous phases.
Fig. 1 Mechanism of action of Diphtheria toxins. (Sharma, N.C., et al., 2019)
Diagnostic Biomarkers for Diphtheria
Early and accurate diagnosis of diphtheria is crucial for initiating prompt therapeutics and preventing severe complications. Biomarkers play a vital role in the diagnostic process by serving as measurable indicators of disease presence or progression.
Diphtheria Toxin
Detection of the toxin in samples, such as throat swabs or blood, can confirm the diagnosis of diphtheria. Various laboratory techniques, including enzyme-linked immunosorbent assay (ELISA) and polymerase chain reaction (PCR), can be employed to detect the toxin accurately.
Bacterial DNA
Specific regions of the Corynebacterium diphtheriae genome can serve as valuable diagnostic biomarkers. By amplifying and analyzing bacterial DNA, PCR tests can provide rapid and sensitive identification of diphtheria infection, aiding in early intervention and containment.
Immunoglobulin
Measurement of specific immunoglobulin levels, such as anti-diphtheria toxin antibodies, can provide insights into the immune response mounted against the bacterium. Western blotting and lateral flow assays are commonly used to assess the presence and levels of immunoglobulins in samples.
IVD Kits for Diphtheria
In the realm of diagnosing infectious diseases like diphtheria, in vitro diagnostic (IVD) kits play a pivotal role in enabling accurate and timely identification of the causative agents or associated biomarkers. Currently, a variety of IVD kits are available for the detection of diphtheria.
Corynebacterium Diphtheriae DNA Detection Kit
PCR kits for diphtheria are designed to detect specific genetic sequences of C. diphtheriae in specimens, providing rapid and accurate identification of the bacterium.
Diphtheria Toxin Detection Kit
ELISA kits are available for the detection of diphtheria toxin in samples. These kits can confirm the presence of the toxin, which is a key diagnostic marker for diphtheria.
Anti-diphtheria Toxin Antibody Detection Kit
Serological assay kits are used to measure the levels of anti-diphtheria toxin antibodies in serum. These kits help assess the immune response to diphtheria and can aid in confirming past exposure or vaccination status.
Our Services
Specializing in delivering cutting-edge in vitro diagnostic (IVD) solutions for rare infectious diseases like diphtheria, our company is dedicated to developing tailor-made antibody, microbial, metabolite and C. diphtheriae genome detection kits to enhance early detection and efficient control of diphtheria. These kits are used in conjunction with auxiliary diagnostic devices to enhance detection sensitivity and specificity.
IVD Product Development Services
Recognizing the importance of point-of-care testing (POCT) in resource-limited settings, our scientists excel in developing rapid diagnostic tests for on-site diphtheria detection. Our companion diagnostic development service focuses on integrating diagnostic tests with specific therapies to achieve personalized therapeutics for diphtheria management.
If you are interested in learning more about our services, please do not hesitate to contact us for additional details and pricing information.
Reference
- Sharma, N.C., Efstratiou, A., Mokrousov, I. et al. Diphtheria. Nat Rev Dis Primers, 2019, 5: 81.
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only and cannot be used to diagnose, treat or manage patients.
