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Malaria

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Malaria

To meet the dynamic demands of malaria diagnostics, our company is dedicated to customizing IVD solutions using state-of-the-art technologies. By developing innovative IVD reagents/kits and portable diagnostic devices, we strive to tackle the complexities of malaria pathogenesis and transform the detection and therapeutics of this infectious disease.

Overview of Malaria

Malaria, a deadly illness caused by Plasmodium parasites and spread through the bites of infected female Anopheles mosquitoes, continues to present a major health crisis worldwide. The disease predominantly affects tropical and subtropical regions, with Africa bearing the highest burden of malaria cases and fatalities. Common symptoms of malaria include fever, chills, anemia, and if left untreated, it can result in severe complications with life-threatening consequences. Therefore, the development of advanced malaria diagnostics is critical to combating this deadly disease and reducing its global impact.

Pathogenesis of malaria.Fig. 1 Pathogenesis of malaria infection. (Saxena, et al., 2017)

Diagnostic Biomarkers for Malaria

Malaria diagnostic biomarkers are specific indicators found in the host's blood or tissues that indicate the presence of Plasmodium or the host's immune response to the infection. Traditional malaria diagnostic methods, like blood smear microscopy and rapid diagnostic tests (RDTs), have limitations in sensitivity, specificity, and speed. Discovering and confirming diagnostic biomarkers present a hopeful pathway for enhancing malaria diagnosis by boosting the precision and effectiveness of assays.

Histidine-Rich Protein 2 (HRP2)

HRP2 is a recognized biomarker frequently employed to identify the most virulent malaria parasite, Plasmodium falciparum. HRP2 is produced by the parasite and can be detected in the host's blood, providing a rapid and specific means of diagnosing Plasmodium falciparum infections.

Plasmodium lactate dehydrogenase (pLDH)

pLDH is another biomarker used to detect various Plasmodium species, including P. falciparum, P. vivax, P. malariae, and P. ovale. pLDH is an enzyme released by the parasite during its life cycle stages, making it a versatile biomarker for diagnosing multiple malaria species.

Plasmodium-specific Nucleic Acids

Plasmodium DNA can be detected using molecular diagnostic techniques like PCR. These biomarkers offer high sensitivity and specificity, enabling the accurate identification of malaria parasite species and the detection of low-level parasitemia in asymptomatic individuals.

IVD Kits for Malaria

In vitro diagnostic (IVD) kits expedite swift and precise malaria diagnosis, enabling prompt therapies. Certain IVD kits can distinguish among different malarial parasites like Plasmodium falciparum, Plasmodium vivax, etc. This distinction is crucial in directing suitable therapeutic strategies.

Kits Applications Detection Methods
Malaria PCR Kit The kit is used to detect specific DNA of Plasmodium, including five human pathogenic species: Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae, Plasmodium ovale and Plasmodium knowlesi. Real-time PCR
Malaria Rapid Test Kit The kit is used to rapidly differentiate Plasmodium falciparum, Plasmodium vivax, Plasmodium ovale and Plasmodium malariae antigens in whole blood. Immunochromatography Assay

Our Services

Our company specializes in offering diagnostic development services for malaria, focusing on creating cutting-edge IVD solutions to address intricate diagnostic hurdles. We excel in crafting nucleic acid, nucleic acid, metabolite , and microbial detection reagents/kits tailored for Plasmodium infection. Leveraging state-of-the-art diagnostic devices, our primary objective is to streamline and automate diagnostic processes, ultimately enhancing diagnostic efficacy.

IVD Product Development Services

In addition to our core offerings, we extend our services by providing point-of-care testing (POCT) and companion diagnostic development services to accelerate prompt diagnosis and individualized therapeutics for malaria. These services are pivotal in enhancing the precision and efficiency of malaria diagnosis, facilitating tailored care strategies for those impacted by the disease.

If you are interested in our services, please feel free to contact us for more details and quotation information of related services.

Reference

  1. Saxena, Richa, et al. "MaLaRia: A cause of anemia and its effect on pRegnancy." World J Anemia 1.2 (2017): 51-62.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

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