Dermatomyositis and polymyositis are systemic inflammatory autoimmune conditions, distinguished by muscle inflammation of varying severity and distinctive skin manifestations specific to dermatomyositis. Positioned as a leader in the field, our company is driving progress in diagnostic innovations for dermatomyositis and polymyositis. We specialize in crafting cutting-edge IVD products and tailored diagnostic solutions for researchers and scientists investigating these intricate autoimmune disorders.

Overview of Dermatomyositis and Polymyositis

Dermatomyositis and polymyositis, the two subtypes of idiopathic inflammatory myositis (IIM), are primarily characterized by symmetrical progressive muscle weakness in the proximal extremities. Both polymyositis and dermatomyositis exhibit a diverse array of symptoms that impact various organs and systems, including the cardiovascular, respiratory, and digestive systems.

Fig.1 Manifestations of IIM. (Connolly, C. M., et al., 2024)

Pathogenesis of Dermatomyositis and Polymyositis

The pathogenesis of these diseases involves intricate immune-mediated processes that induce muscle inflammation and subsequent damage. Despite belonging to the same spectrum of idiopathic inflammatory myositis, polymyositis, and dermatomyositis have unique pathogenic mechanisms. In dermatomyositis, muscle damage is primarily driven by humoral factors (antibodies and the complement system) targeting endomysial capillary endothelial cells. However, polymyositis is predominantly characterized by cytotoxic T cell-mediated muscle fiber injury.

Fig.2 Characteristic histologic features of lesional dermatomyositis skin biopsies. (Cassard, L., et al., 2024)

Biomarkers Development for Dermatomyositis and Polymyositis

Accurate differentiation and diagnosis of polymyositis and dermatomyositis rely heavily on identifying specific biomarkers. Cutting-edge research in proteomics and autoantigen profiling is unveiling novel biomarkers, which may lead to more precise diagnostic tools and targeted therapies. Below are vital biomarkers associated with dermatomyositis and polymyositis:

IVD Kits for Dermatomyositis and Polymyositis

Our Services

Committed to innovation and precision, we specialize in delivering point-of-care testing and companion diagnostic development services that equip healthcare providers to promptly and precisely detect and track these conditions. Through state-of-the-art technologies and premium reagents, we guarantee the reliability and sensitivity of our diagnostic solutions, fostering early detection and improving individual results.

IVD Product Development Services

IVD Reagent/Kit Development

• Proof of Concept and Feasibility
• IVD Reagent/Kit Design Service
• IVD Reagent/Kit Verification
• IVD Reagent/Kit Optimization

IVD Device Development

• Preparation of Device Development Plan
• Prototype Design Service
• Styling Machine Development
• Device Verification and Optimization

As a trusted partner in the quest for diagnostic solutions for polymyositis and dermatomyositis, we work closely with the scientific community to enhance our diagnostic development platforms continually, meeting the evolving requirements of research into dermatomyositis and polymyositis. If you are interested in our services, feel free to reach out to us for additional information and pricing specifics.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.