Celiac disease is a chronic autoimmune disorder primarily impacting the small intestine of genetically predisposed individuals. Our company stands at the forefront of innovation in the field of rare disease diagnosis. Specializing in conditions like celiac disease, we excel in developing IVD reagents and kits that ensure accurate and swift detection.
Overview of Celiac Disease
Celiac disease is an immune-related disorder identified by small intestine enteropathy, systemic symptoms linked to malabsorption and/or immune response, and the presence of autoantibodies targeting tissue transglutaminase (TTG). With estimates suggesting that celiac disease impacts approximately 0.5% to 2% of the worldwide population, accurate detection plays a crucial role in ensuring optimal individual care.
Fig.1 Overview of the celiac lesion. (Iversen, R., and Sollid, L. M. 2023)
Pathogenesis of Celiac Disease
The progression of celiac enteropathy relies on a multifaceted immune reaction to gluten proteins, involving both adaptive and innate responses. The development of celiac disease is characterized by the immune system reacting to gluten ingestion, triggering an assault on the small intestine, resulting in inflammation and harm to its nutrient-absorbing villi. Once these vital structures are compromised, a range of symptoms arises, including diarrhea, weight loss, fatigue, and nutrient deficiencies.
Diagnostic Development for Celiac Disease
Advances in diagnostic techniques, including genetic testing and improved antibody assays, have led to more accurate and efficient detection of celiac disease.
- Antibody-centric diagnostic evaluations identify specific immune markers in the bloodstream triggered by gluten intake. Notably, assays for antibodies like TTG-IgA, TTG-IgG, EMA-IgA, and DGP-IgG have emerged as pivotal biomarkers in celiac disease diagnosis.
- The human leukocyte antigen (HLA) genes, notably the HLA-DQ2 and HLA-DQ8 alleles, are closely associated with susceptibility to celiac disease. By conducting genetic testing for these genetic markers, individuals at elevated risk of developing the condition can be identified.
Fig.2 Diagnostic algorithm for celiac disease. Lebwohl, B., and Rubio-Tapia, A. (2021).
IVD Kits for Celiac Disease
| Types |
Kits |
Applications |
Detection Method |
| Antibody Detection Kit |
EMA-IgA Detection Kit |
Quantitative determination of human EMA (IgA) concentrations in serum |
ELISA |
| TTG-IgG Detection Kit |
Quantitative measurement of IgG class antibodies directed against TTG in serum or plasma |
ELISA |
| TTG-IgA Detection Kit |
Quantitative measurement of IgA class antibodies directed against TTG in human serum or plasma |
ELISA |
| DGP-IgG Detection Kit |
Accurate quantitative measurement of IgG class antibodies against DGP |
ELISA |
| Gene Detection Kit |
HLA-DQ2/8 Gene Detection Kit |
Detection of the HLA-DQ2 and DQ8 alleles |
PCR |
Our Services
To improve precision and efficiency in identifying rare diseases such as celiac disease, our company can offer IVD product development services. By leveraging our proficiency and specialty in diagnostic development areas, we provide cutting-edge solutions that facilitate point-of-care testing and offer comprehensive companion diagnostic development services.
IVD Product Development Services
We are dedicated to providing innovative and tailored diagnostic solutions, equipping healthcare professionals with the necessary tools for early detection of these intricate conditions. This enables prompt intervention and management strategies to enhance the quality of life for those impacted. If you are interested in our state-of-the-art diagnostic services, please feel free to contact us.
References
- Lebwohl, Benjamin, and Alberto Rubio-Tapia. "Epidemiology, Presentation, and Diagnosis of Celiac Disease." Gastroenterology 160.1 (2021): 63-75.
- Iversen, Rasmus, and Ludvig M Sollid. "The Immunobiology and Pathogenesis of Celiac Disease." Annual review of pathology 18 (2023): 47-70.
All of our services and products are intended for preclinical research use
only and cannot be used to diagnose, treat or manage patients.
