Morbillivirus infection is still a public health issue that needs to be addressed. To tackle this challenge, Protheragen invests in advanced technology and skilled professionals, aimed towards the creation of in vitro diagnostic (IVD) solutions. The novel IVD devices and diagnostic test kits that we devise will definitely improve the sensitivity, specificity and stability.
Introduction to Morbillivirus Infection
Morbillivirus belongs to the family paramyxoviridae and is among the highly virulent viruses that can cause human disease. Morbillivirus is contracted mainly through droplets or contact with the sick person and has its primary impact on respiratory and immunity system, causing such symptoms as high fever, dry cough, rhinorrhea and rash. The invention of diagnostic tools for morbillivirus infection is very important in terms of the disease management and control.
Fig. 1 Measles virus replication cycle. (Ferren, M., et al., 2019)
Diagnostic Biomarkers for Morbillivirus Infection
Biomarkers that serve as diagnostics are useful tools in the quest to confirm a morbillivirus infection as they aid in disease detection, monitoring, differentiating it with another ailment, and even determine the effectiveness of a vaccine. Biomarkers used for morbillivirus identification mainly include viral antigens, antibodies and RNA.
Antigen Biomarkers
The presence of viral antigens in respiratory secretions or blood samples is a direct indicator of active viral replication. The key antigens of morbillivirus include nucleocapsid protein and hemagglutinin protein. Morbillivirus infection can be rapidly and reliably detected by ELISA or immunofluorescence techniques.
Antibody Biomarkers
After viral exposure, the host's immune response generates immunoglobulins against morbillivirus antigens, particularly IgM and IgG. Serological assays like the ELISA are able to identify these antibodies, which suggests that the individual had suffered from an infection or received a vaccine in the past.
Viral RNA
A more accurate and specific method of diagnosing a measles virus infection is to detect viral nucleic acids, particularly viral RNA. It can be demonstrated, for example, that the virus is reproducing in a sample because a reverse transcription polymerase chain reaction RT-PCR can detect viral RNA sequences.
IVD Kits for Morbillivirus Infection
Kits for in vitro diagnostics (IVD) are integral in the prompt and precise identification of morbillivirus infections. These kits are created to interact with specific markers associated with morbillivirus infection, which helps in providing beneficial test results that can inform therapeutic options and aid in initiatives geared towards health monitoring and control.
| Kits |
Applications |
Detection Methods |
| Morbillivirus RNA Detection Kit |
Sensitive and specific detection of morbillivirus RNA in samples. |
Reverse Transcription-Polymerase Chain Reaction (RT-PCR) |
| Measles Virus Antibody Test Kit |
Tests for measles virus infection or for antibodies produced by the immune system after receiving the measles vaccine. |
ELISA |
| Measles Virus IgG ELISA Kit |
Detection of measles virus IgG antibodies in human citrate plasma, heparin plasma, and serum samples. |
ELISA |
| Measles Virus Antigen Test Kit |
Rapid test for measles virus antigens, such as nucleocapsid protein or hemagglutinin protein. |
Immunofluorescence |
Our Services
Protheragen's expertise extends to development of advanced in vitro diagnostic (IVD) for morbillivirus infection. We ensure accurate and reliable detection of morbillivirus biomarker by providing all-inclusive services, which includes antigen, antibody and RNA kit development. In addition, we also focus on creating state-of-the-art auxiliary diagnostic devices designed to simplify and automate the disease detection process.
Featured IVD Development Services for Morbillivirus Infection
- Morbillivirus RNA Sequence Development Service
- Morbillivirus Primer and Probe Design Service
- Morbillivirus Antigen Development Service
- Morbillivirus Antibody Development Service
- Quality Control Product Development Service
- And More
IVD Product Development Services
Additionally, we also offer point-of-care testing (POCT) and companion diagnostic development services aimed at promoting quick and convenient at-home testing, as well as customizing therapeutic approaches tailored to individual characteristics of affected individuals and the disease status associated with morbillivirus infection.
If you are interested in learning more about Protheragen's services, please do not hesitate to contact us for additional details and pricing information.
Reference
- Ferren, M., B. Horvat, and C. Mathieu. "Measles encephalitis: towards new therapeutics". Viruses 11: 1017. 2019.
All of our services and products are intended for preclinical research use
only and cannot be used to diagnose, treat or manage patients.
