Japanese encephalitis (JE) represents a significant public health challenge. Through our groundbreaking work in JE research, we lead the way in developing advanced diagnostic tools aimed at improving the effective management of JE cases. Serving as your reliable research collaborator in JE diagnostics, we offer unmatched assistance to address your research requirements comprehensively.
Introduction to Japanese Encephalitis
Japanese encephalitis (JE) is a severe viral infection caused by the Japanese encephalitis virus (JEV), primarily transmitted through mosquito vectors. This disease poses a significant public health threat in many Asian countries, with an estimated 100,000 clinical cases reported annually. JE primarily affects children under 15 years of age, with a high case fatality rate among those who develop severe symptoms.
Fig. 1 Pathogenesis of Japanese encephalitis. (Turtle, et al., 2018)
Diagnostic Biomarkers for Japanese Encephalitis
Diagnostic biomarkers play a critical role in identifying and monitoring diseases like Japanese encephalitis (JE). In the case of JE, biomarkers can help in distinguishing the virus from other similar infections, aiding in timely and accurate diagnosis. These biomarkers can also provide insights into disease progression, severity, and therapeutic responses.
Viral Antigens and Antibodies
In Japanese encephalitis diagnosis, identification of JEV-specific antigens or antibodies in serum or CSF samples can indicate recent infection, providing important insights into the presence of the virus and the immune response against it.
Neurological Biomarkers
Biomarkers that indicate neuronal damage or dysfunction, like neuron-specific enolase (NSE) or glial fibrillary acidic protein (GFAP), can offer valuable information regarding the neurological complications associated with Japanese encephalitis.
Viral Genetic Material
Analyzing the RNA of the JEV helps to identify specific strains of the virus and assess its pathogenicity. Utilizing the PCR method to amplify and detect targeted regions of the viral genetic material allows for swift and sensitive diagnosis of Japanese encephalitis.
IVD Kits for Japanese Encephalitis
In vitro diagnostic (IVD) kits are essential for accurate and timely diagnosis of Japanese encephalitis (JE). These kits are specifically designed to detect biomarkers such as antigens or antibodies associated with Japanese encephalitis virus (JEV) in samples, helping healthcare providers to quickly identify and manage cases of JE.
| Kits |
Applications |
Detection Methods |
| JEV IgG Antibody Detection Kit |
Detection of IgG antibodies against JEV-derived recombinant antigen (JERA) in sera samples. |
ELISA |
| JEV IgM Antibody Detection Kit |
Detection of IgM antibodies in human serum to JEV-derived recombinant antigen (JERA). |
ELISA |
| JEV RNA Detection Kit |
Amplification and detection of JEV RNA in samples. |
RT-PCR |
| JEV Antigen Rapid Test Kit |
Point-of-care testing (POCT) of JEV antigens in samples. |
Lateral flow assays |
Our Services
Our company places a strong emphasis on delivering state-of-the-art IVD solutions tailored for rare infectious diseases such as Japanese encephalitis (JE). We are dedicated to crafting personalized antigen, antibody, and RNA detection kits to bolster early detection and efficient management of JE cases. These kits are designed for use in conjunction with complementary diagnostic equipment to optimize detection sensitivity and specificity.
IVD Product Development Services
Acknowledging the significance of point-of-care testing (POCT) in settings with limited resources, our team of scientists excels in creating rapid diagnostic kits for immediate on-site detection of Japanese encephalitis (JE). Our dedication extends to companion diagnostic development services, emphasizing the integration of diagnostic tests with tailored therapies to facilitate personalized therapeutic strategies for JE.
If you are interested in our services, please feel free to contact us for more details and quotation information of related services.
Reference
- Turtle, Lance, and Tom Solomon. "Japanese encephalitis—the prospects for new treatments." Nature Reviews Neurology 14.5 (2018): 298-313.
All of our services and products are intended for preclinical research use
only and cannot be used to diagnose, treat or manage patients.
