Anthrax represents a significant risk to human health. Our company is committed to developing advanced antigen, antibody, and microbial detection reagents/kits, along with diagnostic equipment, to tackle the complexities associated with anthrax diagnosis. As your trusted ally in anthrax diagnostic exploration, we provide comprehensive and efficient solutions to meet your diverse scientific research needs.
Overview of Anthrax
Anthrax is caused by the bacterium Bacillus anthracis and is a rare but potentially deadly infectious disease. The pathogenesis of anthrax involves anthrax spores of the bacterium entering the human body through inhalation, ingestion, or skin wounds. Once inside the body, the spores germinate, produce toxins, and result in the characteristic symptoms of the disease.
Fig. 1 The infection cycle and pathogenesis of Bacillus anthracis. (Joon S, et al., 2021)
Diagnostic Biomarkers for Anthrax
Anthrax is a serious infectious disease that requires rapid and accurate diagnostic tools for effective identification and control. The in vitro diagnostic (IVD) development of anthrax primarily involves identifying specific biomarkers such as antibodies, antigens, and toxins, each of which can provide unique insights into the presence of the pathogen and the host immune response.
Antibodies
The detection of specific antibodies produced by the host in response to Bacillus anthracis exposure can serve as a valuable marker of infection. Antibody-based assays, such as ELISAs or immunofluorescence assays, can be used to detect the presence of anthrax-specific antibodies in serum samples.
Antigens
In anthrax diagnostics, the detection of bacterial antigens derived from Bacillus anthracis can be indicative of an active infection. For example, lateral flow assays or PCR-based assays targeting specific anthrax antigens, enable the direct identification of the pathogen in samples.
Toxins
Toxins produced by Bacillus anthracis, including edema toxin and lethal toxin, play a central role in the pathogenesis of anthrax and contribute to the severity of the disease. The detection of anthrax toxins in samples can provide valuable insights into the progression of the infection and guide therapeutic decisions.
IVD Kits for Anthrax
In the swift and precise detection of Bacillus anthracis infections, custom-made in vitro diagnostic (IVD) kits designed for anthrax are instrumental. Currently, several commercialized IVD Kits for anthrax have been developed. The table below lists some common IVD Kits.
| Kits |
Applications |
Detection Methods |
| Bacillus Anthracis qPCR Kit |
In vitro detection of Bacillus anthracis genomes. |
qPCR |
| Anthrax Detection Kit |
Serodiagnosis of anthrax infection. |
Lateral flow assays |
| Anthrax ELISA Kit |
In vitro diagnostics of Bacillus anthracis. |
ELISA |
| Anthrax Toxin Receptor 2 (ANTXR2) CLIA Kit |
Detection of anthrax toxin receptor 2 (ANTXR2). |
Chemiluminescent Immunoassay (CLIA) |
Our Services
Specializing in delivering cutting-edge in vitro diagnostic (IVD) solutions for rare infectious diseases like anthrax, our company is dedicated to developing tailor-made antigen, antibody, microbial, and Bacillus anthracis genome detection kits to enhance early detection and efficient control of anthrax. These kits are utilized alongside companion diagnostic devices to maximize detection sensitivity and specificity.
IVD Product Development Services
Optional IVD Products
- Bacillus Anthracis Genome Detection Kit
- Anthrax Antigen Detection Kit
- Anthrax Antibody Detection Kit
- Microbial Detection Kit
- DNA Extraction and PCR Reagents
- And More
Our point-of-care testing (POCT) development service is committed to crafting convenient and user-friendly diagnostic tools for anthrax, facilitating rapid decision-making and therapeutic interventions. Through our companion diagnostic development service, we strive to tailor therapeutic decisions to individual characteristics, enabling personalized therapies.
If you are interested in our services, please feel free to contact us for more details and quotation information of related services.
Reference
- Joon S, Bhatnagar S, Bhatnagar R. Transcriptional regulators in Bacillus anthracis: A potent biothreat agent[J]. Recent Developments in Microbial Technologies, 2021: 367-377.
All of our services and products are intended for preclinical research use
only and cannot be used to diagnose, treat or manage patients.
