Antigen detection is an important way to diagnose diseases. With rich expertise and state-of-the-art technology, our company provides antigen detection reagent/kit development services tailored for different rare diseases, thereby accelerating your process from diagnostic research to commercialization.
Antigen Detection Reagents/Kits for Rare Disease
Antigen detection plays a crucial role in the field of diagnostics, enabling the identification and quantification of specific target molecules in various biological samples. In recent years, there has been notable advancement in the field of rare disease antigen detection. Currently, there are already antigen detection reagents/kits for rare diseases on the market.
| Reagents/Kits |
Antigen |
| Cystic Fibrosis Antigen Detection Reagents/Kits |
Cystic fibrosis transmembrane conductance regulator (CFTR) protein |
| Hereditary Hemochromatosis Antigen Detection Reagents/Kits |
Antigens associated with hereditary hemochromatosis, such as HFE protein |
| Wilson Disease Antigen Detection Reagents/Kits |
Copper-related antigens or proteins, such as ATP7B protein or ceruloplasmin |
| Alpha-1 Antitrypsin Deficiency Antigen Detection Reagents/Kits |
Alpha-1 antitrypsin protein |
| Amyloidosis Antigen Detection Reagents/Kits |
Specific amyloid proteins, such as transthyretin (TTR), immunoglobulin light chains (AL), or serum amyloid A (SAA) |
Fig. 1 Using the urine pregnancy test device as an example, this image illustrates the basic principles behind performing antigen detection. (Pavia, Charles S., and Maria M. Plummer., 2021)
Our Services
Our company leads the way in the development of rare disease antigen detection reagents/kits. With our team of experienced scientists and specialized expertise, we adhere to a rigorous process in the development of antigen detection reagents/kits. This process ensures the utmost quality and reliability of our antigen detection products.
Workflow of Antigen Detection Reagents/Kits Development
Selection and Purification of Target Antigen
Our scientists utilize their profound expertise and extensive research to assist you in identifying antigens specific to rare diseases. Through advanced recombinant protein expression technology and purification techniques such as chromatography, ultrafiltration, and centrifugation, we provide pure and well-characterized antigens for subsequent assay development.
Antibody Screening and Preparation
To detect the target antigen, high-affinity and specific antibodies are crucial. Our company uses hybridoma technology and recombinant antibody production to obtain antibodies that recognize target antigens with exceptional sensitivity and specificity. The selected antibodies are then mass-produced using cell culture technology or recombinant protein expression systems.
Detection Principle and Method Determination
When choosing a detection principle, factors such as sensitivity, specificity, and ease of use need to be considered. Common detection methods include ELISA, lateral flow immunoassay, and immunofluorescence. The choice depends on the specific requirements of the test and the target antigen.
Reagent Formulation and Preparation
This phase involves combining the purified antibodies, suitable buffers, and other necessary components to create a robust and effective detection reagent. The formulation must optimize the sensitivity, specificity, and stability of the assay.
Performance Verification and Optimization
Our scientists test developed reagents using a variety of samples, including positive and negative controls and clinical specimens, to evaluate the performance characteristics of the assays. We use statistical analysis to validate performance parameters and make necessary adjustments to optimize the reagents.
Kit Assembly and Quality Control
We meticulously assemble the antigen detection kits, incorporating all the necessary components for accurate and user-friendly testing. Rigorous quality control measures are implemented at every stage of kit production to ensure batch-to-batch consistency and adherence to the highest quality standards.
Applicable Rare Disease Types
Infectious Diseases
- Malaria (CM)
- Dengue Disease (DF)
- Acquired Immunodeficiency Syndrome (AIDS)
- Hepatitis B and Hepatitis C
- And More
Genetic and Neurological Diseases
- Gaucher Disease (GD)
- Fabry Disease (FD)
- Tay-Sachs Disease (TSD)
- Niemann-Pick Disease (NPD)
- Creutzfeldt-Jakob disease (CJD)
- And More
Cancer
- Prostate Cancer
- Breast Cancer
- Gastrointestinal Cancer
- Ovarian Cancer
- Lung Cancer
- And More
Optional Antigen Types
- Protein antigens are among the most common types used in antigen detection.
- Peptide antigens are short amino acid sequences derived from disease-specific proteins.
- Glycan antigens on cell surfaces or secreted glycoproteins can serve as diagnostic markers.
Our Advantages
Time-saving services with high efficiency
Professional and experienced team
Cutting edge technology platform
Numerous service cases and customer praise
By combining cutting-edge technologies, rigorous quality control, and a multidisciplinary approach, our company continues to drive advancements in antigen detection. If you are interested in our services, please don't hesitate to contact us for further information and pricing details.
References
- Pavia, Charles S., and Maria M. Plummer. "The evolution of rapid antigen detection systems and their application for COVID-19 and other serious respiratory infectious diseases." Journal of Microbiology, Immunology and Infection 54.5 (2021): 776-786.
- Farshchi, Fatemeh, and Mohammad Hasanzadeh. "Nanomaterial based aptasensing of prostate specific antigen (PSA): recent progress and challenges in efficient diagnosis of prostate cancer using biomedicine." Biomedicine & Pharmacotherapy 132 (2020): 110878.
- Kang, Jae Seung, et al. "Limits of serum carcinoembryonic antigen and carbohydrate antigen 19-9 as the diagnosis of gallbladder cancer." Annals of surgical treatment and research 101.5 (2021): 266.
All of our services and products are intended for preclinical research use
only and cannot be used to diagnose, treat or manage patients.
