Enterovirus infection represents a widespread gastrointestinal infectious ailment. Leveraging our profound proficiency in diagnostic research for enterovirus infections, we are capable of creating tailored in vitro diagnostic (IVD) kits and devices to assist you throughout the process from enterovirus infection diagnostic research to commercialization.
Overview of Enterovirus Infection
Enteroviruses constitute a heterogeneous group of viruses capable of inducing an array of illnesses in humans. Infections by enteroviruses can occur through various means of transmission, including the consumption of contaminated food or water, direct contact with infected individuals, and inhalation of airborne droplets. These viruses are particularly renowned for their ability to affect multiple organ systems, leading to a range of diseases from mild respiratory symptoms to severe neurological complications. Enterovirus infections are prevalent worldwide, posing a significant public health concern due to their infectious nature and outbreak potential.
Fig. 1 Molecular mechanisms of immune response to enterovirus (EV) infection. (Wang, Congcong, et al., 2023)
Diagnostic Biomarkers for Enterovirus Infection
Diagnostic biomarkers play a critical role in determining the presence of enteroviruses in samples, distinguishing these infections from other viral diseases, and assessing the severity of the illness. The development of reliable diagnostic biomarkers for enterovirus infections is essential for timely and accurate disease detection, aiding in the effective management of affected individuals and controlling outbreaks.
Viral RNA
The presence of enterovirus RNA in blood or cerebrospinal fluid samples is a direct indicator of active infection. Polymerase chain reaction (PCR) tests that target viral RNA sequences are commonly used for sensitive and specific detection.
Antibodies
The presence of anti-enterovirus antibodies in the serum could suggest a past or current immune reaction to the virus. Serological tests, including ELISA and neutralization assays, detect the presence of enterovirus specific antibodies in a blood sample.
Antigens
Enteroviruses contain multiple antigenic proteins in their particle structure, such as VP1 and VP2 proteins, which can serve as diagnostic biomarkers. Common methods for antigen detection include ELISA and immunofluorescence assay.
IVD Kits for Enterovirus Infection
In vitro diagnostic (IVD) kits designed for enterovirus infections allow for rapid and accurate diagnosis and identification of enterovirus strains. These kits typically contain specific reagents and components required to detect enterovirus antigens, antibodies, or nucleic acids, allowing for rapid identification of the virus in a sample.
| Kits |
Applications |
Detection Methods |
| Enterovirus IgM Antibody Detection Kit |
Qualitative and quantitative detection of anti-enterovirus IgM antibodies in serum or plasma. |
ELISA |
| Enterovirus Rapid Test Kit |
Qualitative detection of enterovirus antigens (VP1 peptide) in stool samples. |
Chromatographic Immunoassay |
| Enterovirus RNA Detection Kit |
Enterovirus RNA detection and virus strain differentiation. |
PCR |
Our Services
By conducting extensive research on the pathogenesis and biomarkers associated with enterovirus infections, we are dedicated to creating groundbreaking IVD products for precise identification and efficient management of this infectious disease. Our range of services encompasses the development of antigen, antibody, and RNA detection kits. With the creation of complementary IVD devices, our aim is to transform the diagnostic paradigm for enterovirus infections.
Recognizing the significance of point-of-care testing (POCT) in environments with limited resources, our researchers specialize in crafting swift diagnostic assays for immediate detection of enterovirus infections. Our services in companion diagnostic development revolve around integrating diagnostic assays with tailored therapeutics to facilitate personalized therapies of enterovirus infections.
If you are interested in our services, please feel free to contact us for more details and quotation information of related services.
Reference
- Wang, Congcong, et al. "Pathogenesis of enterovirus infection in central nervous system." Biosafety and Health 5.04 (2023): 233-239.
All of our services and products are intended for preclinical research use
only and cannot be used to diagnose, treat or manage patients.
