Poliomyelitis is one of the most horrendous communicable diseases that can invade the central nervous system. Thanks to extensive research efforts on poliomyelitis, Protheragen is at the forefront of developing innovative in vitro diagnostic (IVD) tools intended for the better control of poliomyelitis.
Introduction to Poliomyelitis
Poliomyelitis, which is colloquially known as polio, is a form of an infectious disease that is caused by the polio virus. The spectrum of the illness includes mild fever and sore throats as well as paralysis and even death. Poliomyelitis has been a major public health problem for many years. The development of convenient and user-friendly diagnostic tools is paramount for the effective management of poliomyelitis.
Fig. 1 A schematic diagram illustrating the transmission of the poliovirus through the fecal-oral route. (Mbani, Chaldam Jespère, et al., 2023)
Diagnostic Biomarkers for Poliomyelitis
Biomarker research advancements and molecular diagnostics innovations have the potential to ameliorate the poliovirus diagnosis. Poliovirus specific biomarkers would also be useful in early diagnosis, disease severity estimation and evaluation of the response to therapy.
Viral RNA
The existence of viral RNA serves as a direct proof of polio virus infection and is essential to both the diagnosis and the progression of the disease. Real-time PCR can be employed in accurately determining the levels of viral RNA in samples such as cerebrospinal fluids and stool.
Antibodies
The immune response to infection with poliovirus includes the production of specific antibodies such as IgM and IgG. The quantitative and qualitative evaluation of poliovirus-specific antibodies can reveal relevant information regarding prior exposure to the virus.
Markers of Neural Damage
Poliovirus has the capability to inflict severe damage to the neurons, especially in the case of paralytic poliomyelitis. With regards to the CNS injury, neuron-specific enolase (NSE) and myelin basic protein (MBP) are used as neural injury and inflammation biomarkers.
IVD Kits for Poliomyelitis
The invention of in vitro diagnostic (IVD) kits for poliomyelitis diagnosis is a significant contribution to effective testing of the disease. The medical personnel are able to quickly and accurately evaluate and control polio infection because these kits help detect poliovirus through biological samples including cerebrospinal fluid, stool, or blood.
| Kits |
Applications |
Detection Methods |
| Poliovirus Antibody Detection Kit |
Detection and quantification of poliovirus type 1, 2, and 3 IgG antibodies in animal or human serum or plasma. |
ELISA |
| Poliovirus RNA Detection Kit |
Detection and typing of poliovirus. |
RT-PCR |
| Neuron Specific Enolase (NSE) ELISA Kit |
Quantitative determination of neuron specific enolase (NSE) in human serum samples to aid in the identification of central nervous system damage. |
ELISA |
| Myelin Basic Protein (MBP) ELISA Kit |
Quantitative detection of myelin basic protein (MBP) in biological samples to help diagnose and monitor central nervous system damage. |
ELISA |
Our Services
At Protheragen, we specialize in the development of IVD solutions for poliomyelitis. As an organization that values growth and innovation, we concentrate our efforts on the creation of advanced nucleic acid, antibody, and antigen test kits that can accurately detect biomarkers associated with poliomyelitis development. Our aim is to revolutionize the automation and accuracy of poliomyelitis detection through invention of new diagnostic devices.
Customized IVD Development Services for Poliomyelitis
- Polio Virus RNA Sequence Development Service
- Polio Virus Primer and Probe Design Service
- Polio Virus Antigen Development Service
- Polio Virus Antibody Development Service
- Quality Control Product Development Service
- Neurological Injury Biomarker Development Service
IVD Product Development Services
In addition, Protheragen develops point-of-care testing (POCT) and companion diagnostics specific for the diagnosis of poliomyelitis. Through these services, we can help design simple and affordable in vitro diagnostics that are needed to quickly diagnose polio and implement precise therapeutic approaches.
For more information or specific prices about our services, feel free to contact us.
Reference
- Mbani, Chaldam Jespère, et al. "The fight against poliovirus is not over." Microorganisms 11.5 (2023): 1323.
All of our services and products are intended for preclinical research use
only and cannot be used to diagnose, treat or manage patients.
