Cholera is an infectious disease that seriously endangers human health. In tackling the diagnostic hurdles of Cholera, our company commits resources to cutting-edge technologies and expert personnel, focusing on IVD solution advancements. Our groundbreaking diagnostic kits and equipment are poised to greatly improve the sensitivity, specificity, and reliability of testing.
Overview of Cholera
Cholera, stemming from the Vibrio cholerae bacterium, is a serious diarrheal disease capable of inducing swift dehydration and, when untreated, fatality. Primarily impacting areas with inadequate sanitation and tainted water reservoirs, this infectious disease persists as a major public health concern, annually afflicting millions globally. Hence, the expedited creation of precise and quick diagnostic tools is imperative.
Fig. 1 Overview of the Vibrio cholerae life cycle. (Walton M G, et al., 2023)
Diagnostic Biomarkers for Cholera
Diagnostic biomarkers serve as measurable indicators of biological processes or disease states, aiding in the early identification, diagnosis, and monitoring of various medical conditions. In the case of cholera, biomarkers offer valuable insights into the presence of Vibrio cholerae and the host's immune response, facilitating targeted diagnostic strategies and personalized therapeutic approaches.
Cholera Toxin
Cholera toxin (CT), produced by Vibrio cholerae, is a key virulence factor responsible for the characteristic watery diarrhea in affected individuals. Detection of CT in samples, such as stool or serum, can indicate active infection and aid in the rapid diagnosis of cholera.
OmpU Protein
Outer membrane protein U (OmpU) is a surface protein of Vibrio cholerae that plays a role in bacterial adhesion and colonization in the host intestine. Monitoring OmpU levels as a diagnostic biomarker may offer insights into bacterial pathogenesis and infection severity.
O1 and O139 Antigens
The O1 and O139 antigens are surface antigens unique to Vibrio cholerae serogroups O1 and O139, respectively. These antigens can be targeted in diagnostic tests to confirm the presence of Vibrio cholerae and differentiate between different serogroups.
IVD Kits for Cholera
In vitro diagnostic (IVD) kits provide a convenient and standardized method for diagnosing infectious diseases such as cholera. By streamlining the diagnostic process and delivering accurate results promptly, these kits have made significant contributions to effective disease management and epidemic control.
| Kits |
Applications |
Detection Methods |
| Cholera O1/O139 Antigen Detection Kit |
Qualitative detection of Vibrio cholerae O1 and O139 antigens in stool specimens. |
Lateral flow immunochromatographic assay |
| Vibrio Cholerae TaqMan PCR Detection Kit |
Amplification and detection of Vibrio cholerae DNA. |
PCR |
| Cholera Toxin (CT) Detection Kit |
Qualitative detection of cholera toxin (CT). |
ELISA |
| Vibrio Cholerae ELISA Test Kit |
Qualitative detection of antibodies produced by the host immune system in response to Vibrio cholerae infection. |
ELISA |
Our Services
We are a leader in infectious disease diagnostic development services, offering groundbreaking IVD solutions for cholera to meet complex diagnostic needs. Our expertise lies in designing specialized IVD reagents/kits and advanced diagnostic devices tailored specifically for Vibrio cholerae, enhancing diagnostic automation and facilitating the effective management of cholera.
IVD Product Development Services
Optional IVD Products
Recognizing the importance of point-of-care testing (POCT) in resource-limited settings, our scientists excel in developing rapid diagnostic tests for on-site cholera detection. Our companion diagnostic development service focuses on integrating diagnostic tests with specific therapies to achieve personalized therapeutics for cholera management.
If you are interested in our services, please don't hesitate to reach out to us for further information and pricing details on the services we offer.
Reference
- Walton M G, Cubillejo I, Nag D, et al. Advances in cholera research: from molecular biology to public health initiatives[J]. Frontiers in Microbiology, 2023, 14: 1178538.
All of our services and products are intended for preclinical research use
only and cannot be used to diagnose, treat or manage patients.
