Cystic fibrosis (CF) is a complex genetic disease that causes multisystem dysfunction. With our pioneering advancements in CF diagnostic research, we lead the way in creating cutting-edge diagnostic kits and companion diagnostic devices to enhance the precise detection and efficient management of CF. Serving as your trusted ally in CF research, we deliver unmatched support to fulfill all your scientific research requirements.

Introduction to Cystic Fibrosis

Cystic fibrosis (CF) is a hereditary disorder that impacts various organs, predominantly affecting the lungs and pancreas due to the accumulation of thick mucus. This genetic disease is inherited in an autosomal recessive manner and can easily cause death due to lung infections and breathing difficulties. Cystic fibrosis has a higher incidence among Caucasian Americans, with 1 in every 2,500 to 3,500 Caucasian newborns affected by the disease.

Pathophysiology of Cystic Fibrosis

Cystic fibrosis (CF) is caused by mutations in the gene that encodes the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Mutations in the CFTR gene cause the CFTR protein to malfunction, resulting in abnormal production of thick mucus in various organs. The accumulation of mucus creates an ideal environment for bacteria to thrive, leading to recurring lung infections.

Fig. 1 The mechanisms underlying CF and the impact of the purinergic system on the disease's pathophysiology. (Do Carmo, et al., 2021)

IVD Products for Cystic Fibrosis

In vitro diagnostics (IVD) are essential for confirming the presence of cystic fibrosis (CF), identifying specific mutations in the CFTR gene, assessing CFTR protein function, monitoring disease progression, and guiding treatment decisions. There are numerous IVD products available on the market for CF, significantly advancing early detection and precise diagnosis of CF, while also guiding precision treatments for subsequent care.

Our Services

Specializing in tailored in vitro diagnostic (IVD) solutions for rare genetic disorders like cystic fibrosis (CF), our company is dedicated to creating custom CFTR gene testing kits that precisely detect abnormal CFTR mutations in alignment with the disease's pathogenesis. We also contribute to the development of sweat chloride detection kits and immunoreactive trypsinogen (IRT) detection kits for metabolic biomarkers associated with CF, enhancing the speed and accuracy of CF diagnosis.

Workflow of IVD Reagent/Kit Development

Through the creation of advanced complementary diagnostic devices, we streamline the diagnostic workflow for cystic fibrosis (CF), enhancing its automation and efficiency. We offer point-of-care testing and companion diagnostic development services to expedite the diagnosis and precise treatment of CF, facilitating timely and accurate intervention.

IVD Device Development Services

• Preparation of Device Development Plan
• Prototype Design Service
• Styling Machine Development Service
• Device Verification and Optimization Service

If you are interested in our services, please feel free to contact us for more details and quotation information of related services.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.