Helicobacter pylori (H. pylori) infection remains a prevalent global health concern. Committed to pushing the boundaries in H. pylori infection diagnosis, our firm focuses on pioneering technologies and customized solutions. Through the creation of advanced IVD reagents/kits and streamlined diagnostic devices, we strive to tackle the intricacies of H. pylori infection pathogenesis and diagnostic hurdles, revolutionizing the identification and control of this infectious disease.
Introduction to Helicobacter Pylori Infection
Helicobacter pylori, commonly known as H. pylori, is a spiral-shaped bacterium residing in the stomach of humans, garnering significant attention within the realm of gastrointestinal health. This bacterium is a primary culprit behind peptic ulcers and gastritis, and if not addressed, it can escalate to stomach cancer. Research indicates that around 50% to 75% of individuals worldwide might harbor this bacterium, with elevated prevalence rates in developing nations. Therefore, the development of diagnostic tools for H. pylori infection is crucial for timely identification and control of the ailment.
Fig. 1 Pathogenesis of Helicobacter Pylori Infection. (Lenka S, Bhuyan R., 2022)
Diagnostic Biomarkers for Helicobacter Pylori Infection
The identification of reliable biomarkers plays a pivotal role in enhancing the specificity and sensitivity of diagnostic tests for H. pylori. These biomarkers, ranging from antigenic proteins to genetic markers, offer valuable insights into the presence and progression of H. pylori infection.
|
Diagnostic Biomarkers |
Description |
| Urease Enzyme |
Urease enzyme produced by H. pylori is a widely used diagnostic biomarker. Detection of urease enzyme in stool samples is used as a non-invasive method to diagnose active infection. |
| IgG Antibody |
Immunoglobulin G (IgG) antibodies against H. pylori proteins can be detected in blood samples, indicating a current or past infection. |
| Bacterial DNA |
The vacuolating cytotoxin A gene (vacA) of H. pylori encodes the VacA protein, which plays a crucial role in the bacterium's pathogenicity. The PCR method is used to amplify and detect the vacA gene sequence, providing a sensitive and specific method for identifying bacteria. |
IVD Kits for Helicobacter Pylori Infection
In vitro diagnostic (IVD) kits play a crucial role in the early detection of H. pylori infection, enabling prompt intervention and therapeutics. Numerous IVD kits provide non-invasive testing modalities, facilitating swift and accurate identification of the infection.
Urea Breath Test (UBT) Kits
These kits involve the administration of a labeled urea substrate followed by the detection of labeled carbon dioxide in exhaled breath samples. An increase in labeled carbon dioxide indicates the presence of H. pylori in the stomach.
Stool Antigen Test Kits
Stool antigen test kits usually use immunological methods to detect Helicobacter pylori-specific antigens in stool samples. They provide a non-invasive technique for detecting Helicobacter pylori infection with exceptional sensitivity and specificity.
H. pylori Antibody Detection Kits
These kits are typically engineered to identify IgG or IgM antibodies generated during the initial phases of H. pylori infection. They commonly employ serological assays like ELISA and Western blotting to signify present or prior infection with the bacterium.
Molecular Diagnostic Kits
Molecular diagnostic kits are highly sensitive and specific tests for detecting H. pylori infection. These kits use molecular biology techniques, such as PCR or nucleic acid hybridization, to detect DNA fragments of H. pylori and thus confirm infection.
Our Services
We are a leader in infectious disease diagnostic development services, offering groundbreaking IVD solutions for Helicobacter pylori infection to meet complex diagnostic needs. Our expertise lies in designing specialized IVD reagents/kits and advanced diagnostic devices tailored specifically for Helicobacter pylori infection, enhancing diagnostic automation and facilitating the effective management of this disease.
IVD Product Development Services
Optional IVD Products
Additionally, our services include point-of-care testing (POCT) and companion diagnostics development tailored for Helicobacter pylori infection. These offerings are instrumental in facilitating rapid detection and personalized therapies of diseases. If you are interested in our services, please feel free to contact us for more details and quotation information of related services.
Reference
- Lenka S, Bhuyan R. Management of H. pylori induced pepticulcer-a phytotherapeutic approach[J]. J Pure Appl Microbiol, 2022, 16(3): 1530-1537.
All of our services and products are intended for preclinical research use
only and cannot be used to diagnose, treat or manage patients.
