The growing number of monekypox cases throughout the world, as well as the possibility of further spread via human transmission, raises fears that aid monekypox. Protheragen is dedicated to developing diagnostic tools necessary for fast and precise diagnosis of monkeypox disease. We work on the creation of in vitro diagnostic (IVD) kits and advanced diagnostic instruments so that we can assist you in bringing your diagnostic solution from idea to reality.
Introduction to Monkeypox
Monkeypox is a type of zoonotic infection caused by the monkeypox virus and is considered a serious viral disease that negatively impacts both man and animals. This disease is similar to smallpox, but less severe. The onset of this infection is thought to occur from the entry of the infecting agent through any broken skin or mucous membranes and fever, rash and lymphadenopathy follow.
Fig. 1 Transmission of monkeypox virus. (Niu, Liyan, et al., 2023)
Diagnostic Biomarkers for Monkeypox
It is imperative that diagnostic instruments for monkeypox are developed in order to manage and regulate the disease. The use of diagnostic biomarkers that entail monkeypox virus DNA, antigens, and antibodies can provide for effective diagnosis of the virus.
DNA Biomarkers
Monkeypox virion DNA is biomarker used for the diagnosis of the disease and can be detected with the aid of PCR technology. PCR methods can be speedy and accurate, and this is helpful in the making of an early diagnosis, containing outbreaks and monitoring of viral loads.
Antigen Biomarkers
The orthopoxvirus envelope glycoproteins and surface antigen are important antigenic markers in virus diagnosis. They can be tested with different immunoassays, for instance, ELISA or lateral flow assays, to confirm the presence of the virus in a given sample.
Antibody Biomarkers
The presence of specific antibodies directed against the orthopoxvirus monkeypox provide evidence for the diagnosis of monkeypox infection, determination of immunity levels, as well as for vaccination strategies. Such antibodies can be quantified by means of serological tests.
IVD Development for Monkeypox
The advancement of in vitro diagnostic (IVD) tools is critical not only in controlling the monkeypox epidemic, but also in improving the healthcare provided. Such tools can assist in promptly diagnosing individuals suffering from monkeypox and ensure that appropriate therapeutics are administered immediately to avoid the progression of the disease and the dispersal of the virus. As of now, there are a range of IVD kits available in the market which can be used to aid in diagnosing monkeypox.
| Kits |
Applications |
Detection Methods |
| Monkeypox Virus DNA Detection Kit |
Detection of monkeypox virus in serum or lesion exudate samples. |
Real-time PCR |
| Monkeypox Rapid Test Kit |
Point-of-care tests (POCT) for monkeypox virus antigens in exudate from skin lesions, acne scab swabs, or nasal swabs. |
Lateral Flow Assays |
| Monkeypox IgM/IgG Antibody Test Kit |
Rapid detection of monkeypox IgM/IgG antibodies in whole blood, serum, plasma and fingerstick blood specimens. |
Lateral Flow Assays |
Our Services
Through meticulous exploration of monkeypox's pathogenesis, Protheragen is dedicated to pioneering cutting-edge IVD solutions for the accurate detection and efficient control of this infectious disease. We specialize in the development of test kits for DNA, antigens, and antibodies used for testing of the monkeypox virus. Point-of-care testing (POCT) solutions are a part of our strengths as we devise them for self-sampling and home testing for monkeypox.
Customized IVD Development Services for Monkeypox
- Monkeypox Virus DNA Sequence Development Service
- Monkeypox Virus Primer Design Service
- Monkeypox Virus Probe Development Service
- Monkeypox Virus Antigen Development Service
- Monkeypox Virus Antibody Development Service
- Monkeypox Virus Assay Development Service
- Quality Control Product Development Service
- And More
IVD Product Development Services
Protheragen maintains its devotion towards developing best complementary IVD devices for the automation of monkeypox testing while ensuring maximum efficiency. Moreover, our client-oriented companion diagnostic development services centers on the approach of combining specific therapeutics for a precision management of monkeypox.
If you are interested in learning more about our services, please do not hesitate to contact us for additional details and pricing information.
Reference
- Niu, Liyan, et al. "Insights into monkeypox pathophysiology, global prevalence, clinical manifestation and treatments." Frontiers in Immunology 14 (2023): 1132250.
All of our services and products are intended for preclinical research use
only and cannot be used to diagnose, treat or manage patients.
