Hashimoto's thyroiditis, characterized by thyroid-specific autoantibodies, stands as one of the most prevalent autoimmune conditions. Our company leads the way in Hashimoto's thyroiditis diagnostic development by combining state-of-the-art technologies, innovative research practices, and a team of experienced professionals. We offer extensive diagnostic development solutions for researchers and scientists to improve the precision and specificity of Hashimoto's thyroiditis diagnostics.
Overview of Hashimoto's Thyroiditis
Hashimoto's thyroiditis, also known as chronic lymphocytic or autoimmune thyroiditis, represents an autoimmune thyroid ailment distinguished by an enlarged thyroid volume, lymphocyte infiltration of the gland's tissue, and the presence of antibodies targeting specific thyroid antigens. In this condition, the immune system generates antibodies that attack proteins within the thyroid, notably thyroid peroxidase (TPO) and thyroglobulin. More prevalent in women, its occurrence ranges from 0.3 to 1.5 cases per 1000 individuals.
Fig.1 Pathogenesis of Hashimoto's thyroiditis. (Jin, B., et al., 2022)
Pathogenesis of Hashimoto's Thyroiditis
The development of Hashimoto's thyroiditis is intertwined with a complex interplay of genetic components, environmental factors, and epigenetic influences. The pathogenesis of HT is closely associated with autoantibodies and a notable lymphocytic infiltration comprising B and T cells within the thyroid tissue. As time progresses, the persistent inflammation and damage to thyroid tissue can lead to a reduction in thyroid hormone production, ultimately culminating in the demise of thyroid cells and hypothyroidism.
Fig.2 The breakdown of immune tolerance leads to autoimmunity. (Ralli, M., et al., 2020)
Diagnostics Development for Hashimoto's Thyroiditis
Blood Testing
Blood tests offer valuable information regarding thyroid function and the detection of specific antibodies linked to Hashimoto's thyroiditis. Below is essential blood tests frequently employed in diagnosing Hashimoto's thyroiditis:
- Thyroid hormones (T3 and T4)
- Thyroid-stimulating hormone (TSH)
- Thyroid peroxidase antibodies
- Thyroglobulin antibodies
- And more
Genetic Testing
Genetic diagnosis of Hashimoto's thyroiditis entails pinpointing particular genetic variations that could predispose an individual to develop the condition. Numerous genetic variations have been linked to heightened susceptibility:
- Interleukin-2 receptor alpha (IL2RA)
- Human leukocyte antigen (HLA)
- Chemokines
- CTL-associated antigen-4 (CTLA4)
- And more
IVD Kits for Hashimoto's Thyroiditis
| Kits |
Applications |
Method of Detection |
| TSH Detection Kit |
Quantitative detection of TSH in human serum and plasma samples |
ELISA |
| T4 Detection Kit |
Quantitate T4 in serum, plasma, and other biological fluids |
ELISA |
| Antibodies to Thyroglobulin Detection Kit |
Quantitate antibodies to thyroglobulin in human serum, plasma, or cell culture medium |
ELISA |
| Antibodies to Thyroid Peroxidase Detection Kit |
Quantitative determination of autoantibodies to thyroid peroxidase |
ELISA |
Our Services
Our dedication to innovation and partnerships with leading experts guarantee our position at the vanguard of diagnostic progress. We are committed to creating cutting-edge IVD products for precise and rapid detection. Additionally, we offer point-of-care testing and companion diagnostic development services to expedite the diagnosis and personalized therapy of Hashimoto's thyroiditis.
IVD Product Development Services
Drawing upon our expertise and profound understanding of autoimmune conditions, we can provide reliable and prompt diagnostic solutions for researchers to support early detection, personalized therapy strategies, and enhanced individual outcomes in the management of Hashimoto's thyroiditis.
If you are interested in our services, please do not hesitate to contact us for more information.
References
- Ralli, Massimo et al. "Hashimoto's thyroiditis: An update on pathogenic mechanisms, diagnostic protocols, therapeutic strategies, and potential malignant transformation." Autoimmunity reviews 19.10 (2020): 102649.
- Jin, Binghui et al. "Pathogenesis Markers of Hashimoto's Disease-A Mini Review." Frontiers in bioscience (Landmark edition) 27.10 (2022): 297.
All of our services and products are intended for preclinical research use
only and cannot be used to diagnose, treat or manage patients.
