Autoimmune diseases represent a group of complex conditions. Our company is dedicated to advancing autoimmune disease diagnostics through a range of specialized services. Our expertise includes developing IVD reagents and kits for accurate disease detection, and designing and manufacturing IVD equipment for precise testing. Working with us, you will receive professional support to accelerate the commercialization of your diagnostic products.
Introduction to Autoimmune Diseases
Autoimmune diseases are a group of disorders characterized by an abnormal immune response where the body's immune system mistakenly attacks its own tissues and organs. This immune system dysfunction leads to inflammation, tissue damage, and impaired organ function. Classic examples of autoimmune diseases include rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, type 1 diabetes, etc.
Fig. 1 The actions of autoantibodies in immunopathology. (Pisetsky D S., 2023)
Biomarkers of Autoimmune Disease Diagnostics
Biomarkers play a crucial role in the diagnosis, prognosis, and monitoring of autoimmune diseases. These measurable indicators provide valuable information about disease activity, severity, and response to treatment. In the realm of autoimmune diseases, various biomarkers are utilized to aid in accurate diagnosis and management.
Autoantibodies
Autoantibodies mistakenly attack the body's own tissues, leading to autoimmune reactions, and they are commonly used as diagnostic biomarkers. For instance, antinuclear antibodies (ANA) target components of the cell nucleus and are present in diseases such as systemic lupus erythematosus, rheumatoid arthritis, and Sjögren's syndrome.
Inflammatory Markers
Inflammatory markers indicate the presence and extent of inflammation in the body, which is a common feature of many autoimmune diseases. For example, C-reactive protein (CRP) is a protein produced by the liver in response to inflammation. Elevated CRP levels are associated with autoimmune diseases and can be used to monitor disease activity.
Serum Protein Biomarkers
Serum protein biomarkers are proteins present in the blood that can indicate the occurrence of autoimmune diseases. Cytokines are signaling proteins involved in immune responses. Abnormal levels of cytokines, such as tumor necrosis factor-alpha, can indicate autoimmune diseases such as rheumatoid arthritis and inflammatory bowel disease.
Market Size of Autoimmune Disease Diagnostics
According to the latest report, the autoimmune disease diagnostics market in the United States was valued at around $2.65 billion in 2023. It is expected to reach approximately $4.48 billion by 2033, with a compound annual growth rate of 5.4% during the forecast period from 2023 to 2033.
Fig. 2 Autoimmune disease diagnostics market size. (Source: Nova One Advisor Market Research Report)
Our Services
The autoimmune disease diagnostics market is showing a year-on-year growth trend. Focusing on this field, we are dedicated to developing innovative IVD products for autoimmune diseases. Utilizing disease-specific biomarkers such as autoantibodies, inflammatory markers, and serum protein biomarkers, we specialize in creating high-precision and highly specific diagnostic reagents/kits for rare autoimmune diseases. We also develop complementary diagnostic equipment, providing a one-stop solution for autoimmune disease diagnostics development.
Types of Rare Autoimmune Diseases
| A-B |
| Acquired Aplastic Anemia |
Autoimmune Hemolytic Anemia |
| Acute Disseminated Encephalomyelitis |
Autoimmune Hepatitis |
| Acute Hemorrhagic Leukoencephalitis |
Autoimmune Hypophysitis |
| Adult-onset Still's Disease |
Autoimmune Myocarditis |
| Allergic Rhinitis |
Autoimmune Oophoritis |
| Alopecia Areata |
Autoimmune Orchitis |
| Ankylosing Spondylitis |
Autoimmune Pancreatitis |
| Antiphospholipid Syndrome |
Autoimmune Progesterone Dermatitis |
| Asthma |
Autoimmune Pulmonary Alveolar Proteinosis |
| Autoimmune Addison's Disease |
Axial Spondyloarthritis |
| Autoimmune Encephalitis |
Balo Disease |
| Autoimmune Gastritis |
Behcet Disease |
| Autoimmune Gastrointestinal Dysmotility |
Bullous Pemphigoid |
| C-G |
| Celiac Disease |
Dermatomyositis and Polymyositis |
| Chronic Inflammatory Demyelinating Polyneuropathy |
Discoid Lupus Erythematosus |
| Chronic Obstructive Pulmonary Disease |
Endometriosis |
| Chronic Prostatitis/Chronic Pelvic Pain Syndrome |
Eosinophilic Fasciitis |
| Chronic Recurrent Multifocal Osteomyelitis |
Evans Syndrome |
| Churg-Strauss Syndrome |
Febrile Infection-Related Epilepsy Syndrome |
| Clinically Isolated Syndrome |
Glomerulonephritis |
| Cold Agglutinin Disease |
Goodpasture's Syndrome |
| CREST Syndrome |
Gout |
| Crohn's Disease |
Granulomatosis with Polyangiitis |
| Dermatitis Herpetiformis |
Graves' Disease |
| H-N |
| Hashimoto's Thyroiditis |
Lupus Nephritis |
| Henoch-Schönlein Purpura |
Marfan Syndrome |
| Idiopathic Membranous Nephropathy |
Ménière's Disease |
| IgA Nephropathy |
Microscopic Polyangiitis |
| Immune Thrombocytopenia |
Mixed Connective Tissue Disease |
| Interstitial Cystitis |
Multiple Sclerosis |
| Interstitial Lung Disease |
Myasthenia Gravis |
| Juvenile Dermatomyositis |
Myositis |
| Juvenile Idiopathic Arthritis |
Necrobiosis Lipoidica |
| Lambert-Eaton Myasthenic Syndrome |
Neuromyelitis Optica Spectrum Disorder |
| Linear IgA Bullous Dermatosis |
Neurosarcoidosis |
| O-P |
| Ocular Cicatricial Pemphigoid |
Pemphigus Vulgaris |
| Opsoclonus-Myoclonus-Ataxia Syndrome |
Pernicious Anemia |
| Optic Neuritis |
POEMS Syndrome |
| Palindromic Rheumatism |
Polyarteritis Nodosa |
| Palmoplantar Pustulosis |
Polycystic Ovary Syndrome |
| Paraneoplastic Cerebellar Degeneration |
Polymyalgia Rheumatica |
| Paraneoplastic Pemphigus |
Primary Biliary Cholangitis |
| Paroxysmal Nocturnal Hemoglobinuria |
Primary Sclerosing Cholangitis |
| Parsonage-Turner Syndrome |
Psoriasis |
| Pelvic Inflammatory Disease |
Psoriatic Arthritis |
| Pemphigus Foliaceus |
Pure Red Cell Aplasia |
| R-Z |
| Rasmussen Encephalitis |
Stiff Person Syndrome |
| Raynaud's Syndrome |
Systemic Lupus Erythematosus |
| Reactive Arthritis |
Systemic Lupus Erythematosus (SLE) |
| Recurrent Pericarditis |
Systemic Sclerosis |
| Relapsing Polychondritis |
Transverse Myelitis |
| Rheumatic Fever |
Type 1 Diabetes |
| Rheumatoid Arthritis |
Ulcerative Colitis |
| Sarcoidosis |
Undifferentiated Connective Tissue Disease |
| Scleroderma |
Uveitis |
| Sjögren's Syndrome |
Vasculitis |
| Small Fiber Neuropathy |
Vitiligo |
Our IVD Product Development Services
We also provide point-of-care diagnostics and companion diagnostics development services for autoimmune diseases. These services enable rapid detection of biomarkers associated with autoimmune conditions, facilitating early diagnosis and personalized treatment strategies tailored to individual patients.
If you are interested in our services, please feel free to contact us for more details and quotation information of related services.
References
- Pisetsky D S. Pathogenesis of autoimmune disease[J]. Nature Reviews Nephrology, 2023, 19(8): 509-524.
- Witte M, Zillikens D, Schmidt E. Diagnosis of autoimmune blistering diseases[J]. Frontiers in medicine, 2018, 5: 296.
All of our services and products are intended for preclinical research use
only and cannot be used to diagnose, treat or manage patients.
