Sjögren's syndrome presents as a chronic autoimmune condition marked by dryness in the eyes and mouth due to impaired function of the tear and saliva glands. With a dedicated team of experts specializing in rare diseases, our company provides comprehensive diagnostic development services tailored to this area. These services include cutting-edge IVD products, point-of-care testing, and companion diagnostic development services, to cater to the requirements of researchers and scientists in this specialized field.
Overview of Sjögren's Syndrome
Sjögren's syndrome, a chronic autoimmune disorder, is characterized by numerous lesions. Its primary symptoms include dryness in the mouth and eyes, accompanied by systemic complications like pulmonary issues, kidney damage, and lymphoma. The incidence rate of Sjögren's syndrome stands at 6.92 per 100,000 person-years, with a prevalence rate of 60.82 cases per 100,000 individuals.
The pathogenesis of this condition involves various critical mechanisms, including abnormal activation of the innate immune response, particularly via the interferon (IFN) and NF-κB pathways, irregular recruitment to lymphoid follicles facilitated by CXCR5, and T cell activation alongside rising HLA susceptibility along the IL-12/IFN-γ axis.
Fig.1 Typical manifestations of Sjögren's syndrome. (Zhan, Q., et al., 2023)
Biomarkers Development for Sjögren's Syndrome
Biomarkers serve not only as quantitative measures for precise diagnosis but also play a crucial role in evaluating disease progression and monitoring responses to therapy. Here are some key biomarkers commonly associated with Sjögren's syndrome:
Blood Biomarkers
Typical serological findings include autoantibodies like antinuclear antibodies, rheumatoid factor, and Ro/SSA and La/SSB autoantibodies. Additionally, Flt-3L shows promise as a potential biomarker for lymphoma development in primary Sjögren's syndrome.
Salivary Biomarkers
Various salivary proteins can help differentiate Sjögren's syndrome, such as salivary β2-microglobulin, calprotectin, neutrophil gelatinase-associated lipocalin, carbonic anhydrase VI, and sialic acid-binding immunoglobulin-like lectin-5.
Lacrimal Biomarker
Cathepsin S, a cysteine endopeptidase involved in antigen presentation and immunity, has shown increased activity in tear samples from individuals with Sjögren's syndrome. This suggests that cathepsin S activity could be a biomarker for the condition.
Other Biomarkers
The oral microbiome of Sjögren's syndrome individuals with salivary hypofunction appears to be under stress and dysregulated. Veillonella parvula has emerged as a potential biomarker for Sjögren's syndrome, indicating its diagnostic potential in this context.
IVD Kits for Sjögren's Syndrome
| Kits |
Applications |
Method of detection |
| Anti-SSA/Ro Antibody ELISA Kit |
Qualitative determination of human anti-SSA/Ro antibody concentrations in serum and plasma |
ELISA |
| Anti-SSB/La Antibody ELISA Kit |
Measures anti-SSB antibodies in the serum and plasma |
ELISA |
| Sjögren Syndrome Panel |
Detect the levels of ANA, RF, Ro, La, and CENP in blood samples |
Indirect Immunofluorescence and Fluoroenzyme immunoassay (FEIA) |
| Antinuclear Antibody Spectrum Detection Kit |
Detect the levels of antinuclear antibodies |
ELISA |
Our Services
Our dedication to excellence shines through in our customized solution for diagnostic development, which incorporates cutting-edge technology and methodologies. We aim to deliver comprehensive solutions for developing IVD products, from discovering innovative biomarkers to enhancing diagnostic devices for prompt and precise identification.
Through a concentration on innovation, accuracy, and individual-centric practices, we provide point-of-care testing and companion diagnostic development services to create a significant influence in rare disease diagnosis. Our ultimate aim is to enhance results and quality of life for individuals with Sjögren's syndrome. If you are interested in our services, please don't hesitate to contact us for further information and quotes.
Reference
- Zhan, Qipeng et al. "Pathogenesis and treatment of Sjogren's syndrome: Review and update." Frontiers in immunology 14 (2023): 1127417.
All of our services and products are intended for preclinical research use
only and cannot be used to diagnose, treat or manage patients.
