Tuberculosis (TB), a prevalent respiratory infectious disease, poses significant public health challenges. Our company boasts a team of adept researchers and scientists specializing in tuberculosis diagnosis, dedicated to advancing cutting-edge IVD solutions. We offer point-of-care testing (POCT) and companion diagnostic development services to expedite tuberculosis diagnosis and facilitate personalized therapeutic strategies.
Introduction to Tuberculosis
Tuberculosis (TB) is a highly infectious disease caused by the bacterium Mycobacterium tuberculosis. While primarily impacting the lungs, TB can also target organs like the brain, spine, or kidneys. Transmitted through the air, TB poses a significant worldwide public health challenge, impacting millions annually. The development of precise diagnostic tools for TB detection has the potential to enhance therapeutic effectiveness and outcomes for individuals affected by this disease on a global scale.
Fig. 1 Schematic diagram of the manifestations and pathophysiology of tuberculosis infection. (Stewart, Paul, et al., 2023)
Diagnostic Biomarkers for Tuberculosis
Diagnostic biomarkers play a critical role in tuberculosis (TB) testing by serving as indicators that help identify the presence of TB infection in individuals. These biomarkers provide valuable insights into the disease process, aiding in the accurate and timely diagnosis of TB.
Interferon-gamma (IFN-γ)
IFN-γ is produced by T cells when stimulated by TB-specific antigens, making it a key player in the immune response to TB infection. Interferon-gamma release assays (IGRAs) utilize the measurement of IFN-γ levels to detect latent TB infection, distinguishing it from active disease.
Lipoarabinomannan (LAM)
Lipoarabinomannan is a cell wall component of Mycobacterium tuberculosis that serves as a diagnostic biomarker for TB infection. LAM is detectable in body fluids like urine, making it particularly useful for diagnosing TB in individuals with HIV co-infection.
Bacterial DNA
DNA-based biomarkers provide a promising avenue for TB diagnosis, offering unique advantages in sensitivity and specificity. Nucleic acid amplification tests (NAATs) like PCR and LAMP leverage DNA biomarkers to achieve rapid and accurate TB diagnosis.
IVD Development for Tuberculosis
In vitro diagnostics (IVD) use laboratory techniques to identify the presence of Mycobacterium tuberculosis in a sample, providing a non-invasive, rapid method for diagnosing tuberculosis (TB), especially in resource-limited settings. Based on diagnostic biomarkers of TB, a variety of IVD kits can be developed to accurately detect TB infection.
| Kits |
Applications |
Detection Methods |
| Interferon-gamma Release Assays (IGRAs) Kits |
Measurement of interferon-γ levels released by T cells in response to tuberculosis-specific antigens. |
IGRA |
| Lipoarabinomannan (LAM) Detection Kits |
Identification of LAM in body fluids such as urine. |
Lateral Flow Assays, Immunofluorescence Assays |
| Mycobacterium Tuberculosis DNA Detection Kits |
Detection of Mycobacterium tuberculosis DNA in samples. |
PCR, LAMP |
Our Services
By conducting comprehensive research on the pathogenesis and metabolic pathways of tuberculosis (TB), we are dedicated to pioneering innovative IVD solutions for the precise identification and effective management of this infectious disease. Our specialized services encompass the creation of a range of IVD reagents/kits designed to swiftly and accurately detect TB-related biomarkers. Additionally, we offer expertise in the development of portable diagnostic devices aimed at enhancing the automation and efficiency of TB diagnosis procedures.
Recognizing the critical role of point-of-care testing (POCT) in resource-constrained environments, our team of scientists excels in developing swift diagnostic assays for immediate tuberculosis (TB) identification on-site. Our companion diagnostic development services are tailored to merge diagnostic tests with tailored therapies, facilitating personalized therapeutic strategies for effective tuberculosis (TB) management.
If you are interested in learning more about our services, please do not hesitate to contact us for additional details and pricing information.
Reference
- Stewart, Paul, et al. "Role of B cells in Mycobacterium tuberculosis infection." Vaccines 11.5 (2023): 955.
All of our services and products are intended for preclinical research use
only and cannot be used to diagnose, treat or manage patients.
