In our efforts to alleviate the impact of tetanus, a potentially life-threatening condition, our company is dedicated to innovating cutting-edge in vitro diagnostic (IVD) reagents/kits and accompanying diagnostic devices aimed at overcoming the obstacles in tetanus diagnosis. Serving as your dependable ally in tetanus diagnostic research, we offer robust and inclusive solutions tailored to fulfill your scientific research requirements effectively.
Introduction to Tetanus
Tetanus, commonly referred to as lockjaw, is a serious bacterial infection triggered by Clostridium tetani. This bacterium generates a potent neurotoxin that impacts the nervous system, resulting in muscle rigidity and spasms. A classic symptom of tetanus is stiffness of the jaw muscles, which can progress to affect muscles throughout the body. In regions with limited medical resources, tetanus remains a significant health concern.
Fig. 1 Schematic diagram of the mechanism of action of tetanus toxin. (Boer, Menno, et al., 2024)
Diagnostic Biomarkers for Tetanus
The diagnosis of tetanus relies on the identification of specific biomarkers associated with the disease. Diagnostic biomarkers play a crucial role in accurately detecting and monitoring tetanus infections, guiding appropriate interventions, and assessing therapeutic outcomes.
Tetanus Toxin
The presence of tetanus toxin in the bloodstream serves as a key diagnostic biomarker for tetanus infection. Detection of tetanus toxin antibodies or fragments can confirm exposure to the neurotoxin produced by Clostridium tetani, providing valuable information for diagnosis and therapeutic planning.
Neurological Biomarkers
Biomarkers related to neurological function, such as neuron-specific enolase (NSE) and S100 calcium-binding protein B (S100B), can provide insights into the impact of tetanus toxin on the central nervous system. Changes in these biomarkers may indicate neuronal damage and dysfunction.
Bacterial DNA
DNA from Clostridium tetani represents a valuable and specific diagnostic biomarker. Molecular techniques like polymerase chain reaction (PCR) amplification are employed to detect the bacterial DNA in the sample, offering a precise and dependable means of confirming tetanus.
IVD Kits for Tetanus
In vitro diagnostic (IVD) kits are formulated to identify particular biomarkers or pathogens in samples, offering prompt and dependable diagnostic solutions that can facilitate prompt interventions and enhance therapeutic efficacy. There are currently various IVD kits available on the market for tetanus, which facilitate the diagnosis of tetanus.
| Kits |
Applications |
Detection Methods |
| Tetanus IgG ELISA Kit |
Qualitative and quantitative detection of tetanus IgG antibodies in samples. |
ELISA |
| Tetanus Rapid Test Kit |
Rapid and point-of-care testing (POCT) for Clostridium tetani in samples. |
Lateral Flow Assay |
| Clostridium Tetani DNA Test Kit |
Identification of Clostridium tetani neurotoxin gene fragments. |
Real-time Recombinase Polymerase Amplification Assay |
Our Services
At our company, we provide a wide array of IVD solutions tailored to address the intricate diagnostic needs associated with tetanus. Our specialization involves the development of antigen, antibody, and nucleic acid reagents and kits dedicated to tetanus, enabling early detection and precise diagnosis of this infectious disease. Through the creation of cutting-edge IVD devices, our key objective is to streamline diagnostic procedures, ultimately enhancing operational efficiency.
Recognizing the significance of point-of-care testing (POCT) in environments with limited resources, our researchers specialize in creating swift diagnostic assays for on-site tetanus testing. Our companion diagnostic development services concentrate on merging diagnostic assays with tailored therapeutics to facilitate individualized therapies for tetanus.
If you are interested in our services, please feel free to contact us for more details and quotation information of related services.
Reference
- Boer, Menno, et al. "Tetanus–a case report highlighting the challenges in diagnosis and treatment." Tropical Diseases, Travel Medicine and Vaccines 10.1 (2024): 10.
All of our services and products are intended for preclinical research use
only and cannot be used to diagnose, treat or manage patients.
