The development of sophisticated diagnostic tools is crucial in combating rickettsial infections. With our groundbreaking research in rickettsial infections, we are at the forefront of developing cutting-edge IVD products to improve the effective management of this complex infectious disease. As your trusted ally in rickettsial infection research, we offer unmatched support to address your scientific research requirements.
Overview of Rickettsial Infection
Rickettsial infections, caused by a diverse group of bacteria transmitted through vectors like fleas, lice, ticks, or mites, pose a significant public health concern globally. These infections comprise a range of diseases such as Queensland tick typhus, scrub typhus, Flinders Island spotted fever, and murine typhus. While relatively rare, cases have been reported in specific regions of Australia, emphasizing the importance of understanding and effectively diagnosing these conditions.
Fig. 1 Schematic representation of the life cycle of tick-borne rickettsiae. (Kim, Hwan Keun, 2022)
Diagnostic Biomarkers for Rickettsial Infection
Rickettsial infections are difficult to diagnose due to their diverse presentations and overlapping symptoms with other febrile illnesses. Identification of specific biomarkers has the potential to improve the accuracy and efficiency of diagnosing rickettsial infections, thereby enabling timely therapeutic interventions and improving therapeutic outcomes.
Antigen Biomarkers
Specific proteins or components of the bacteria causing Rickettsia infections can serve as diagnostic biomarkers. Diagnostic tests based on antigen detection have the ability to rapidly detect and capture active infections.
Antibody Biomarkers
IgM and IgG antibodies generated by the immune system in reaction to rickettsial infections serve as crucial diagnostic biomarkers. IgM antibodies signify recent or acute infections, whereas IgG antibodies suggest previous infections or immunity.
IVD Development for Rickettsial Infection
The development of advanced in vitro diagnostic (IVD) kits is critical for the accurate and timely detection of rickettsial infections. These IVD kits are developed specifically for specific biomarkers associated with rickettsial pathogens to ensure a high degree of specificity in the diagnosis of these infections.
Rickettsia Antigen Detection Kit
Antigen detection kits play a vital role in the rapid and specific identification of active rickettsial infection. Using lateral flow immunoassays or enzyme-linked immunosorbent assays (ELISAs), these kits can sensitively detect rickettsial antigens in blood samples.
Rickettsia Antibody Detection Kit
Rickettsia antibody detection kits are crucial for diagnosing past and current infections, as well as determining immune status and therapeutic response. These kits typically utilize ELISA or immunofluorescence detection methods to detect IgM and IgG antibodies.
Our Services
To address the unmet needs in in vitro diagnostics (IVD) for rickettsial infections, our company is dedicated to creating a range of kits for detecting antigens, antibodies, and microbes to precisely diagnose this uncommon infectious disease. Through the development of compatible IVD devices, our goal is to enhance detection sensitivity, specificity, and durability.
Furthermore, our offerings encompass point-of-care testing (POCT) and the development of companion diagnostics tailored for rickettsial infections. These solutions expedite swift disease identification and enable personalized therapeutic interventions. If you are interested in our services, please feel free to contact us for more details and quotation information of related services.
Reference
- Kim, Hwan Keun. "Rickettsia -Host-Tick Interactions: Knowledge Advances and Gaps." Infection and Immunity (2022).
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only and cannot be used to diagnose, treat or manage patients.
