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Plague

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Plague

Plague, an infectious disease with a remarkably high mortality rate, presents diagnostic challenges. In response, our company invests in cutting-edge technology and proficient professionals focused on IVD solution development. Our pioneering diagnostic kits and equipment are poised to enhance detection sensitivity, specificity, and stability significantly.

Overview of Plague

Plague, caused by the bacterium Yersinia pestis, has claimed millions of lives throughout history. This zoonotic disease, typically transmitted through flea bites, manifests in three primary forms: bubonic, septicemic, and pneumonic plague. The most common bubonic plague infects the lymph nodes; septicemic plague affects the bloodstream; while pneumonic plague targets the lungs. Plague is now rare, with approximately 1,000 to 2,000 cases diagnosed worldwide each year. Given its high fatality rate, there is an urgent need for innovative diagnostic solutions to enhance accurate detection and timely therapeutics of this disease.

Modes of transmission of Yersinia pestis.Fig. 1 The transmission modes and pathogenic mechanisms of Yersinia species in humans. (Heroven, K., et al., 2014)

Diagnostic Biomarkers for Plague

Due to the diverse clinical presentations and rapid spread of plague, diagnosis poses a significant challenge. Diagnostic biomarkers offer a targeted approach to detecting the presence of bacteria or their associated toxins in biological samples, aiding in early diagnosis and intervention. By identifying unique biomarkers specific to plague infection, healthcare providers can promptly initiate appropriate therapeutic strategies, thereby reducing the incidence and mortality rates associated with this infectious disease.

F1 Antigen

The F1 antigen, a major protein produced by Yersinia pestis, has been extensively studied as a diagnostic biomarker for plague. Detection of F1 antigen in samples, such as blood or sputum, can indicate an active infection.

LcrV Protein

The LcrV protein, which plays a crucial role in the pathogenesis of Yersinia pestis, has also shown promise as a diagnostic biomarker. Its presence in samples may serve as an indicator of plague infection.

Plague-Specific Antibodies

Antibodies produced by the host in response to Yersinia pestis infection can be detected as biomarkers of plague. Immunological assays targeting these antibodies can provide valuable diagnostic information.

IVD Development for Plague

Developing innovative in vitro diagnostic (IVD) kits based on diagnostic biomarkers for plague can aid in the accurate and rapid detection of Yersinia pestis infection. These IVD kits are equipped with advanced detection technologies, with the potential to revolutionize plague diagnostics, enhance therapeutic outcomes, and improve public health surveillance.

Kits Applications Detection Methods
Antigen Detection Kits These kits are designed to detect the presence of F1 antigen and LcrV protein in samples. Immunoassays, Lateral Flow Assays
Antibody Detection Kits These kits are used to detect antibodies against Yersinia pestis infection in samples. ELISA
Nucleic Acid Detection Kits These kits are utilized for detecting Yersinia pestis DNA. PCR

Our Services

As pioneers in the field of plague diagnostics, we offer cutting-edge IVD solutions tailored for Yersinia pestis infection, addressing intricate diagnostic requirements. Our proficiency involves crafting specialized antigen, antibody, DNA, and microbial detection kits for plague, enabling swift identification and timely intervention. These IVD kits, utilized alongside our diagnostic devices, optimize detection precision and dependability.

In addition, our company is dedicated to developing quick and convenient point-of-care diagnostic tests for immediate on-site diagnosis and prompt therapeutic decisions. We offer tailored solutions for companion diagnostics to guarantee personalized therapeutic approaches and enhance treatment results.

If you are interested in our services, please don't hesitate to reach out to us for further information and pricing details on the services we offer.

Reference

  1. Heroven, Ann Kathrin, and Petra Dersch. "Coregulation of host-adapted metabolism and virulence by pathogenic yersiniae." Frontiers in cellular and infection microbiology 4 (2014): 146.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.