In vitro diagnostic (IVD) development plays a pivotal role in the early detection of Lassa fever. Our company is committed to pioneering innovative antigen and RNA regents/kits as well as automated diagnostic devices that tackle the inherent complexity and diagnostic challenges associated with Lassa fever pathology.
Introduction to Lassa Fever
Lassa fever, a viral hemorrhagic illness prevalent in West Africa, poses significant public health challenges due to its potential for severe illness and mortality. Caused by the Lassa virus, primarily transmitted by Mastomys rats, this disease manifests with symptoms ranging from mild fever, fatigue, and headaches to severe manifestations like hemorrhaging and organ failure. The virus can be contracted through contact with infected rodents or individuals. The development of advanced in vitro diagnostic (IVD) tools is crucial for the effective control of diseases.
Fig. 1 Structure and replication strategy of Lassa virus. (Garry, Robert F, 2023)
Diagnostic Biomarkers for Lassa Fever
Diagnostic biomarkers for Lassa fever play a pivotal role in differentiating it from other febrile illnesses common in endemic regions. By identifying specific molecular signatures associated with Lassa virus infection, biomarkers offer a non-invasive and efficient means of diagnosis.
Viral Antigens
Viral antigens, like the nucleoprotein and glycoprotein of the Lassa virus, are specific components of the virus that trigger the host's immune response. Detecting these viral antigens in a sample enables direct identification of the virus, facilitating early diagnosis of Lassa fever.
Viral RNA
Viral RNA is another key diagnostic biomarker for Lassa fever, especially early in the infection when viral replication is active. Techniques such as reverse transcription polymerase chain reaction (RT-PCR) are able to amplify and detect Lassa viral RNA in samples with high sensitivity and specificity.
IVD Development for Lassa Fever
Developing in vitro diagnostics (IVD) for Lassa fever is crucial for accurate and timely detection of this infectious disease, especially in endemic regions where it poses a significant public health threat. IVD development for Lassa fever primarily involves creating diagnostic kits that can accurately detect Lassa virus in samples.
Antigen Detection Kit Development
ELISA kits can be designed to identify specific antigens of the Lassa virus, such as the nucleoprotein or glycoprotein. Another option is to develop rapid diagnostic tests for detecting viral antigens using lateral flow technology, enabling quick and convenient on-site testing.
RNA Detection Kit Development
Reverse transcription polymerase chain reaction (RT-PCR) detection methods can be employed to create kits capable of amplifying and detecting Lassa virus RNA in samples with exceptional sensitivity and specificity. These kits play a critical role in the precise identification of Lassa virus.
Our Services
With a profound comprehension of the pathogenesis of Lassa fever, our company is dedicated to pioneering innovative IVD solutions for the precise identification and efficient management of this viral illness. Our offerings encompass the creation of antigen and RNA test kits alongside complementary diagnostic equipment. Notably, we excel in crafting point-of-care testing (POCT) products to facilitate swift detection and prompt therapeutics of Lassa fever.
IVD Product Development Services
In order to ensure precise therapies for Lassa fever, we offer companion diagnostic development services. These services aid in determining the most suitable therapeutic options for affected individuals by examining specific biomarkers or genetic markers linked to the disease. If you are interested in our services, please feel free to contact us for more details and quotation information of related services.
Reference
- Garry, Robert F. "Lassa fever—the road ahead." Nature Reviews Microbiology 21.2 (2023): 87-96.
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