At the forefront of diagnostic research for Acinetobacter infections, our company offers pioneering solutions to elevate the detection and surveillance of Acinetobacter infections. We are dedicated to developing inventive IVD kits and devices that will markedly enhance the sensitivity, specificity, and reliability of detection.
Introduction to Acinetobacter Infection
Acinetobacter baumannii is a type of Gram-negative bacterium that has become an important nosocomial pathogen, with worrisome levels of antibiotic resistance. This opportunistic pathogen, named after the bacteriologist Paul Baumann, primarily affects individuals with compromised immune systems. The prevalence of Acinetobacter infections, especially those caused by multidrug-resistant strains, poses a significant challenge to the global healthcare environment.
Fig. 1 Cell envelope and surface-associated virulence factors of Acinetobacter baumannii. (Mea, Hing Jian, et al., 2021)
Diagnostic Biomarkers for Acinetobacter Infection
Accurate and reliable diagnostic biomarkers help with early detection of Acinetobacter infections, guide therapeutic decisions, and monitor therapeutic responses. By identifying biomarkers associated with the pathogenesis of Acinetobacter and antibiotic resistance, healthcare providers can diagnose the disease and tailor therapies to improve therapeutic outcomes for affected individuals.
Outer Membrane Protein A (OmpA)
OmpA is a key virulence factor in Acinetobacter baumannii and has been implicated in host cell adherence and invasion. Elevated levels of OmpA may serve as a potential biomarker for the presence of Acinetobacter baumannii and the severity of infection.
Efflux Pump Proteins
Efflux pump proteins, such as AdeB and AdeDE, are important components of the antibiotic resistance mechanism in Acinetobacter species. Detection of efflux pump proteins can indicate the presence of multidrug-resistant Acinetobacter strains.
Antibodies
The presence of Acinetobacter-specific antibodies in serum samples suggests prior exposure to the pathogen and the initiation of an immune response. Utilizing antibody-based diagnostic assays like ELISA provides a sensitive and specific means of detection.
Genetic Materials
Specific genetic determinants, such as genes encoding antibiotic resistance mechanisms or virulence factors, can serve as diagnostic biomarkers. Molecular diagnostic techniques, such as PCR, can rapidly and accurately identify resistance genes in isolates.
IVD Development for Acinetobacter Infection
In vitro diagnostic (IVD) kits play a crucial role in the accurate and timely detection of Acinetobacter infections, especially in healthcare settings where rapid diagnosis is essential for effective disease management. Based on diagnostic biomarkers for Acinetobacter infection and combined with advanced diagnostic technologies, a variety of IVD kits targeting Acinetobacter infection can be developed.
| Kits |
Applications |
Detection Methods |
| Acinetobacter Baumannii Gene Detection Kit |
Qualitative detection of specific genes in Acinetobacter baumannii. |
PCR |
| Acinetobacter Baumannii Antibody Detection Kit |
Detection of specific antibodies associated with Acinetobacter infection in samples. |
ELISA |
| Acinetobacter Baumannii Antigen Detection Kit |
Point-of-care testing (POCT) for Acinetobacter baumannii antigen. |
Lateral Flow Assays |
| Antimicrobial Susceptibility Testing (AST) Kit |
These kits are used to determine the susceptibility of Acinetobacter isolates to various antibiotics, guiding the selection of appropriate antimicrobial therapy. |
Disk Diffusion Method |
Our Services
Specializing in diagnostic development services for Acinetobacter infections, our company provides an extensive array of IVD solutions to address intricate diagnostic needs. Our proficiency lies in crafting nucleic acid, antigen, antibody, or microbial detection reagents/kits tailored for Acinetobacter baumannii, facilitating prompt detection and precise diagnosis of this grave infectious disease. Leveraging state-of-the-art diagnostic devices, our primary aim is to streamline and automate diagnostic processes, ultimately enhancing operational efficacy.
Recognizing the significance of point-of-care testing (POCT) in environments with limited resources, our researchers specialize in creating quick diagnostic tests for immediate on-site identification of Acinetobacter infection. Our companion diagnostic development services concentrate on integrating diagnostic tests with tailored therapies to facilitate individualized therapeutics of Acinetobacter infection.
If you are interested in our services, please feel free to contact us for more details and quotation information of related services.
Reference
- Mea, Hing Jian, Phelim Voon Chen Yong, and Eng Hwa Wong. "An overview of Acinetobacter baumannii pathogenesis: Motility, adherence and biofilm formation." Microbiological research 247 (2021): 126722.
All of our services and products are intended for preclinical research use
only and cannot be used to diagnose, treat or manage patients.
