Human T-lymphotropic virus type 1 (HTLV-1) infection is widespread globally. In response to the intricate challenges of diagnosing HTLV-1 infection, our company has allocated substantial resources towards incorporating state-of-the-art technology and skilled professionals to develop IVD solutions. Our innovative diagnostic kits and devices are poised to greatly elevate the sensitivity, specificity, and dependability of detection.
Overview of HTLV-1 Infection
Human T-lymphotropic virus type 1 (HTLV-1) is a retrovirus classified within the HTLV family. It targets CD4+ T cells and is linked to several health conditions, such as adult T-cell lymphoma (ATL) and HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). HTLV-1 is characterized by its ability to integrate into the host genome as a provirus, leading to persistent lifelong infection in affected individuals.
Fig. 1 Mechanisms of HTLV cell infection. (Forlani G, et al., 2021)
Diagnostic Biomarkers for HTLV-1 Infection
Human T-lymphotropic virus type 1 (HTLV-1) infection presents unique challenges in diagnosis due to its asymptomatic nature in most individuals. The recognition of particular diagnostic biomarkers is pivotal in the timely detection, tracking the advancement of the disease, and directing therapeutic choices for conditions linked to HTLV-1.
HTLV-1 Viral DNA
Measuring the presence of HTLV-1 viral DNA in peripheral blood to determine the proviral load is a crucial indicator for evaluating the degree of viral infection. Increased levels of proviral loads are associated with an escalated likelihood of developing diseases connected to HTLV-1.
HTLV-1 Antibodies
Conducting a serological test on a blood sample to detect antibodies targeted at HTLV-1 antigens (like Gag, Env, or Tax proteins) is a prevalent approach for diagnosing HTLV-1 infection. ELISA is one of the most commonly used serological tests.
CD4+ T Cell Activation Markers
HTLV-1 infection leads to the activation and proliferation of CD4+ T cells. Markers of T cell activation, such as CD25 and HLA-DR, can serve as diagnostic indicators of HTLV-1 infection and associated inflammatory conditions.
IVD Kits for HTLV-1 Infection
In the realm of medical diagnostics, the utilization of in vitro diagnostic (IVD) kits stands as pivotal in the accurate identification of HTLV-1 infection. These advanced tools not only aid in the timely identification of pathogens but also serve as crucial assets in mitigating transmission risks and promoting public health and well-being.
| Kits |
Applications |
Detection Methods |
| HTLV-1 Antibody Detection Kits |
Confirm the presence of specific antibodies against HTLV-1 antigens. |
ELISA or Immunoassay |
| HTLV-1 PCR Kits |
Used to amplify and detect HTLV-1 genetic material (proviral DNA) in samples, thereby providing a quantitative measure of viral load. |
PCR |
| CD4+ T Cell Activation Marker Detection Kits |
Analysis of T cell activation and surface markers. |
Flow Cytometry |
Our Services
At our company, we are dedicated to advancing IVD solutions for human T-lymphotropic virus type 1 (HTLV-1) infection. Our primary focus lies in creating HTLV-1 DNA and antibody detection kits to precisely distinguish HTLV-1 infection from other infectious diseases that present similar symptoms. Through the development of point-of-care testing (POCT) kits, our goal is to streamline the swift screening of pathogens in settings where resources are limited.
IVD Product Development Services
By innovating advanced complementary diagnostic devices, we optimize the diagnostic process for HTLV-1 infection, improving its automation and overall efficiency. Additionally, our companion diagnostic development services are tailored towards attaining precise therapies for HTLV-1 infection.
If you are interested in our services, please feel free to contact us for more details and quotation information of related services.
Reference
- Forlani G, Shallak M, Accolla R S, et al. HTLV-1 infection and pathogenesis: new insights from cellular and animal models[J]. International Journal of Molecular Sciences, 2021, 22(15): 8001.
All of our services and products are intended for preclinical research use
only and cannot be used to diagnose, treat or manage patients.
