Antiphospholipid syndrome (APS) is a thrombo-inflammatory disorder that adds complexity to around one-third of systemic lupus erythematosus cases, indicating the likelihood of increased organ damage as time progresses. Our company is committed to pushing forward diagnostic solutions for APS, providing point-of-care testing, developing companion diagnostics, fostering the creation of IVD products, and ultimately enhancing individual outcomes within APS.
Overview of Antiphospholipid Syndrome
APS with an estimated prevalence of 40 to 50 cases per 100,000 and an annual incidence of 1 to 2 per 100,000, is characterized by antiphospholipid antibodies in the bloodstream. These antibodies maliciously target phospholipid-binding proteins, instigating a hypercoagulable state that results in blood clots in both arteries and veins. Beyond the macrovascular clots, individuals with APS are prone to microvascular thrombosis affecting a myriad of organs, including the skin, eyes, heart, lungs, and kidneys.
Fig.1 Other manifestations are sometimes associated with APS. (Knight, J. S., et al., 2023)
Pathogenesis of Antiphospholipid Syndrome
The pathophysiology of APS is driven by circulating antiphospholipid antibodies which precipitate vascular thrombosis and obstetrical complications. These antibodies interact with phospholipids and associated binding proteins located on cell surfaces, triggering the activation of the endothelium, platelets, and leukocytes, skewing the circulating intravascular milieu toward in situ thrombosis, and promoting other autoimmune and inflammatory repercussions.
Fig.2 Cellular and molecular mechanisms of obstetric APS. (Alijotas-Reig, J., et al., 2022)
Diagnostic Development for Antiphospholipid Syndrome
The standards for diagnosing APS entail the detection of antiphospholipid antibodies like anticardiolipin antibodies, anti-β2GPI antibodies, and lupus anticoagulants. The goal of creating APS diagnostic kits utilizing these antibodies as biomarkers is to enhance the precision, efficiency, and accessibility of diagnosing this autoimmune disorder.
IVD Kits for Antiphospholipid Syndrome
| Kits |
Applications |
Detection Methods |
| Anticardiolipin Antibodies Detection Kit |
Detection of anticardiolipin antibodies in serum, including IgG and IgM |
ELISA |
| Anti-β2GPI Antibodies Detection Kit |
Detection of anti-β2GPI antibodies in serum, including IgG and IgM |
ELISA |
| Anti-prothrombin/phosphatidylserine Antibodies Detection Kit |
Detection of IgG and IgM class antibodies to phosphatidylserine/prothrombin complex in serum or plasma |
ELISA |
| Lupus Anticoagulants Detection Kit |
For quantitative detection of lupus anticoagulants in plasma |
Clotting assays (DRVVT, SCT, or APTT) |
Our Services
Harnessing our avant-garde technology and expertise, we offer comprehensive integrated diagnostic development services. From the nascent stages of research to the meticulous phases of product design and validation, we provide end-to-end services that accelerate the innovation of diagnostic tools. Our mission is to achieve rapid and accurate detection, facilitating timely diagnosis and intervention for APS individuals.
IVD Product Development Services
We provide comprehensive support for developing IVD products tailored for APS diagnosis and also provide
point-of-care testing and
companion diagnostic development services. By fostering and actively cultivating an innovative environment, and consistently exploring fresh technologies and methods to boost the precision and effectiveness of APS diagnosis.
If you are interested in our services, please don't hesitate to
contact us for further information and pricing details.
References
- Knight, Jason S et al. "Antiphospholipid syndrome: advances in diagnosis, pathogenesis, and management." BMJ (Clinical research ed.) 380 (2023): e069717.
- Alijotas-Reig, Jaume et al. "Pathogenesis, Diagnosis and Management of Obstetric Antiphospholipid Syndrome: A Comprehensive Review." Journal of clinical medicine 11.3 (2022): 675.
All of our services and products are intended for preclinical research use
only and cannot be used to diagnose, treat or manage patients.
